Ehrnhoefer DE - Search Results

1

Mouse models of Huntington disease: variations on a theme.

Ehrnhoefer DE, Butland SL, Pouladi MA, Hayden MR. Ehrnhoefer DE, et al. Dis Model Mech. 2009 Mar-Apr;2(3-4):123-9. doi: 10.1242/dmm.002451. Dis Model Mech. 2009. PMID: 19259385 Free PMC article.

2

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.

Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Ehrnhoefer DE, et al. Hum Mol Genet. 2006 Sep 15;15(18):2743-51. doi: 10.1093/hmg/ddl210. Epub 2006 Aug 7. Hum Mol Genet. 2006. PMID: 16893904

3

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.

Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, Lipton SA. Okamoto S, et al. Among authors: ehrnhoefer de. Nat Med. 2009 Dec;15(12):1407-13. doi: 10.1038/nm.2056. Epub 2009 Nov 15. Nat Med. 2009. PMID: 19915593 Free PMC article.

4

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.

Pouladi MA, Xie Y, Skotte NH, Ehrnhoefer DE, Graham RK, Kim JE, Bissada N, Yang XW, Paganetti P, Friedlander RM, Leavitt BR, Hayden MR. Pouladi MA, et al. Among authors: ehrnhoefer de. Hum Mol Genet. 2010 Apr 15;19(8):1528-38. doi: 10.1093/hmg/ddq026. Epub 2010 Jan 22. Hum Mol Genet. 2010. PMID: 20097678 Free PMC article.

5

Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.

Ehrnhoefer DE, Sutton L, Hayden MR. Ehrnhoefer DE, et al. Neuroscientist. 2011 Oct;17(5):475-92. doi: 10.1177/1073858410390378. Epub 2011 Feb 10. Neuroscientist. 2011. PMID: 21311053 Free PMC article. Review.

6

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.

Carroll JB, Southwell AL, Graham RK, Lerch JP, Ehrnhoefer DE, Cao LP, Zhang WN, Deng Y, Bissada N, Henkelman RM, Hayden MR. Carroll JB, et al. Among authors: ehrnhoefer de. Mol Neurodegener. 2011 Aug 19;6:59. doi: 10.1186/1750-1326-6-59. Mol Neurodegener. 2011. PMID: 21854568 Free PMC article.

7

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.

Ehrnhoefer DE, Wong BK, Hayden MR. Ehrnhoefer DE, et al. Nat Rev Drug Discov. 2011 Oct 21;10(11):853-67. doi: 10.1038/nrd3556. Nat Rev Drug Discov. 2011. PMID: 22015920 Free PMC article. Review.

8

Caspase-6 and neurodegeneration.

Graham RK, Ehrnhoefer DE, Hayden MR. Graham RK, et al. Among authors: ehrnhoefer de. Trends Neurosci. 2011 Dec;34(12):646-56. doi: 10.1016/j.tins.2011.09.001. Epub 2011 Oct 22. Trends Neurosci. 2011. PMID: 22018804 Review.

9

A quantitative method for the specific assessment of caspase-6 activity in cell culture.

Ehrnhoefer DE, Skotte NH, Savill J, Nguyen YT, Ladha S, Cao LP, Dullaghan E, Hayden MR. Ehrnhoefer DE, et al. PLoS One. 2011;6(11):e27680. doi: 10.1371/journal.pone.0027680. Epub 2011 Nov 29. PLoS One. 2011. PMID: 22140457 Free PMC article.

10

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR. Uribe V, et al. Among authors: ehrnhoefer de. Hum Mol Genet. 2012 May 1;21(9):1954-67. doi: 10.1093/hmg/dds005. Epub 2012 Jan 18. Hum Mol Genet. 2012. PMID: 22262731 Free PMC article.

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