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A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy.
Sawamura M, Tachikawa K, Hikawa R, Akiyama H, Kaji S, Yasuda K, Leu AI, Hong H, Mukthavaram R, Chivukula P, Yamakado H, Hirabayashi Y, Takahashi R, Matsuzawa SI. Sawamura M, et al. Among authors: kaji s. Mol Ther Nucleic Acids. 2024 Nov 5;35(4):102380. doi: 10.1016/j.omtn.2024.102380. eCollection 2024 Dec 10. Mol Ther Nucleic Acids. 2024. PMID: 39640012 Free PMC article.
Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis.
Kaji S, Berghoff SA, Spieth L, Schlaphoff L, Sasmita AO, Vitale S, Büschgens L, Kedia S, Zirngibl M, Nazarenko T, Damkou A, Hosang L, Depp C, Kamp F, Scholz P, Ewers D, Giera M, Ischebeck T, Wurst W, Wefers B, Schifferer M, Willem M, Nave KA, Haass C, Arzberger T, Jäkel S, Wirths O, Saher G, Simons M. Kaji S, et al. Immunity. 2025 Jan 14;58(1):263. doi: 10.1016/j.immuni.2024.11.024. Epub 2024 Dec 4. Immunity. 2025. PMID: 39637851 No abstract available.
311 results