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Differential effects of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs modified at position C2 on tubulin polymerization, binding, and conformational changes.
Barbier P, Peyrot V, Sarrazin M, Rener GA, Briand C. Barbier P, et al. Among authors: peyrot v. Biochemistry. 1995 Dec 26;34(51):16821-9. doi: 10.1021/bi00051a033. Biochemistry. 1995. PMID: 8527458
The S-isomer is a more potent antimitotic compound than the R-isomer, and the two isomers differ markedly in binding to tubulin [Leynadier, D., Peyrot, V., Sarrazin, M., Briand, C., Andreu, J. M., Rener, G. A., & Temple, C., Jr. (1993) Biochemistry 32, 10675-106 …
The S-isomer is a more potent antimitotic compound than the R-isomer, and the two isomers differ markedly in binding to tubulin [Leynadier, …
Kinetics of association and dissociation of two enantiomers, NSC 613863 (R)-(+) and NSC 613862 (S)-(-) (CI 980), to tubulin.
Barbier P, Peyrot V, Dumortier C, D'Hoore A, Rener GA, Engelborghs Y. Barbier P, et al. Among authors: peyrot v. Biochemistry. 1996 Feb 13;35(6):2008-15. doi: 10.1021/bi951987y. Biochemistry. 1996. PMID: 8639685
For the S-isomer, the direct fluorescence stopped-flow study showed that the signals were largely imputable to the fluorescence of the binding at low-affinity sites [Leynadier, D., Peyrot, V., Sarrazin, M., Briand, C., Andreu, J. M., Rener, G. A., & Temple, C., …
For the S-isomer, the direct fluorescence stopped-flow study showed that the signals were largely imputable to the fluorescence of the bindi …
The active GTP- and ground GDP-liganded states of tubulin are distinguished by the binding of chiral isomers of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate.
Barbier P, Peyrot V, Leynadier D, Andreu JM. Barbier P, et al. Among authors: peyrot v. Biochemistry. 1998 Jan 13;37(2):758-68. doi: 10.1021/bi970568t. Biochemistry. 1998. PMID: 9425100
They induce formation of abnormal polymers from purified GTP-Mg-tubulin, the active assembly form of tubulin, in glycerol-free buffer with magnesium [De Ines, C., Leynadier, D., Barasoain, I., Peyrot, V., Garcia, P., Briand, C., Rener, G. A., and Temple, C., Jr. (19 …
They induce formation of abnormal polymers from purified GTP-Mg-tubulin, the active assembly form of tubulin, in glycerol-free buffer with m …
80 results