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A conserved protonation-dependent switch controls drug binding in the Abl kinase.
Shan Y, Seeliger MA, Eastwood MP, Frank F, Xu H, Jensen MØ, Dror RO, Kuriyan J, Shaw DE. Shan Y, et al. Among authors: shaw de. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):139-44. doi: 10.1073/pnas.0811223106. Epub 2008 Dec 24. Proc Natl Acad Sci U S A. 2009. PMID: 19109437 Free PMC article.
How does a drug molecule find its target binding site?
Shan Y, Kim ET, Eastwood MP, Dror RO, Seeliger MA, Shaw DE. Shan Y, et al. Among authors: shaw de. J Am Chem Soc. 2011 Jun 22;133(24):9181-3. doi: 10.1021/ja202726y. Epub 2011 May 13. J Am Chem Soc. 2011. PMID: 21545110 Free PMC article.
Architecture and membrane interactions of the EGF receptor.
Arkhipov A, Shan Y, Das R, Endres NF, Eastwood MP, Wemmer DE, Kuriyan J, Shaw DE. Arkhipov A, et al. Among authors: shaw de. Cell. 2013 Jan 31;152(3):557-69. doi: 10.1016/j.cell.2012.12.030. Cell. 2013. PMID: 23374350 Free PMC article.
Transitions to catalytically inactive conformations in EGFR kinase.
Shan Y, Arkhipov A, Kim ET, Pan AC, Shaw DE. Shan Y, et al. Among authors: shaw de. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7270-5. doi: 10.1073/pnas.1220843110. Epub 2013 Apr 1. Proc Natl Acad Sci U S A. 2013. PMID: 23576739 Free PMC article.
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.
Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammarén H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR. Shan Y, et al. Among authors: shaw de. Nat Struct Mol Biol. 2014 Jul;21(7):579-84. doi: 10.1038/nsmb.2849. Epub 2014 Jun 11. Nat Struct Mol Biol. 2014. PMID: 24918548 Free PMC article.
272 results