Barile E - Search Results

1

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors.

De SK, Chen LH, Stebbins JL, Machleidt T, Riel-Mehan M, Dahl R, Chen V, Yuan H, Barile E, Emdadi A, Murphy R, Pellecchia M. De SK, et al. Among authors: barile e. Bioorg Med Chem. 2009 Apr 1;17(7):2712-7. doi: 10.1016/j.bmc.2009.02.046. Epub 2009 Feb 26. Bioorg Med Chem. 2009. PMID: 19282190 Free PMC article.

2

Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase.

De SK, Stebbins JL, Chen LH, Riel-Mehan M, Machleidt T, Dahl R, Yuan H, Emdadi A, Barile E, Chen V, Murphy R, Pellecchia M. De SK, et al. Among authors: barile e. J Med Chem. 2009 Apr 9;52(7):1943-52. doi: 10.1021/jm801503n. J Med Chem. 2009. PMID: 19271755 Free PMC article.

3

Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors.

Johnson SL, Chen LH, Barile E, Emdadi A, Sabet M, Yuan H, Wei J, Guiney D, Pellecchia M. Johnson SL, et al. Among authors: barile e. Bioorg Med Chem. 2009 May 1;17(9):3352-68. doi: 10.1016/j.bmc.2009.03.040. Epub 2009 Mar 26. Bioorg Med Chem. 2009. PMID: 19359184 Free PMC article.

4

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.

De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M. De SK, et al. Among authors: barile e. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. doi: 10.1016/j.bmc.2009.12.013. Epub 2009 Dec 11. Bioorg Med Chem. 2010. PMID: 20045647 Free PMC article.

5

Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway.

Barile E, De SK, Carlson CB, Chen V, Knutzen C, Riel-Mehan M, Yang L, Dahl R, Chiang G, Pellecchia M. Barile E, et al. J Med Chem. 2010 Dec 9;53(23):8368-75. doi: 10.1021/jm100825h. Epub 2010 Nov 9. J Med Chem. 2010. PMID: 21062009 Free PMC article.

6

Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase.

De SK, Barile E, Chen V, Stebbins JL, Cellitti JF, Machleidt T, Carlson CB, Yang L, Dahl R, Pellecchia M. De SK, et al. Among authors: barile e. Bioorg Med Chem. 2011 Apr 15;19(8):2582-8. doi: 10.1016/j.bmc.2011.03.017. Epub 2011 Mar 12. Bioorg Med Chem. 2011. PMID: 21458276 Free PMC article.

7

Design and NMR studies of cyclic peptides targeting the N-terminal domain of the protein tyrosine phosphatase YopH.

Leone M, Barile E, Dahl R, Pellecchia M. Leone M, et al. Among authors: barile e. Chem Biol Drug Des. 2011 Jan;77(1):12-9. doi: 10.1111/j.1747-0285.2010.01058.x. Epub 2010 Nov 30. Chem Biol Drug Des. 2011. PMID: 21118379 Free PMC article.

8

Synthesis and SAR studies of dual AKT/NF-κB inhibitors against melanoma.

Barile E, De SK, Feng Y, Chen V, Yang L, Ronai Z, Pellecchia M. Barile E, et al. Chem Biol Drug Des. 2013 Nov;82(5):520-533. doi: 10.1111/cbdd.12177. Epub 2013 Sep 25. Chem Biol Drug Des. 2013. PMID: 23790042 Free PMC article.

9

PDK1 inhibitors.

Barile E, De SK, Pellecchia M. Barile E, et al. Pharm Pat Anal. 2012 May;1(2):145-63. doi: 10.4155/ppa.12.17. Pharm Pat Anal. 2012. PMID: 24236780 Free PMC article. Review.

10

NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.

Barile E, Pellecchia M. Barile E, et al. Chem Rev. 2014 May 14;114(9):4749-63. doi: 10.1021/cr500043b. Epub 2014 Apr 8. Chem Rev. 2014. PMID: 24712885 Free PMC article. Review. No abstract available.

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