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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: nielsen af. Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12. Nucleic Acids Res. 2009. PMID: 19282453 Free PMC article.
Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.
Rahbek UL, Nielsen AF, Dong M, You Y, Chauchereau A, Oupicky D, Besenbacher F, Kjems J, Howard KA. Rahbek UL, et al. Among authors: nielsen af. J Drug Target. 2010 Dec;18(10):812-20. doi: 10.3109/1061186X.2010.527982. Epub 2010 Oct 27. J Drug Target. 2010. PMID: 20979442
Best practice standards for circular RNA research.
Nielsen AF, Bindereif A, Bozzoni I, Hanan M, Hansen TB, Irimia M, Kadener S, Kristensen LS, Legnini I, Morlando M, Jarlstad Olesen MT, Pasterkamp RJ, Preibisch S, Rajewsky N, Suenkel C, Kjems J. Nielsen AF, et al. Nat Methods. 2022 Oct;19(10):1208-1220. doi: 10.1038/s41592-022-01487-2. Epub 2022 May 26. Nat Methods. 2022. PMID: 35618955 Free PMC article. Review.
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine.
Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community Working Groups. Rajewsky N, et al. Nature. 2021 Apr;592(7852):E8. doi: 10.1038/s41586-021-03287-8. Nature. 2021. PMID: 33731935 Free PMC article. No abstract available.
26 results