Sakai R - Search Results

1

Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.

Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikaïnen OT, Swanson GT, Kastrup JS. Frydenvang K, et al. Among authors: sakai r. J Biol Chem. 2009 May 22;284(21):14219-29. doi: 10.1074/jbc.M808547200. Epub 2009 Mar 18. J Biol Chem. 2009. PMID: 19297335 Free PMC article.

2

Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.

Sakai R, Swanson GT, Shimamoto K, Green T, Contractor A, Ghetti A, Tamura-Horikawa Y, Oiwa C, Kamiya H. Sakai R, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):650-8. J Pharmacol Exp Ther. 2001. PMID: 11160654

3

Differential activation of individual subunits in heteromeric kainate receptors.

Swanson GT, Green T, Sakai R, Contractor A, Che W, Kamiya H, Heinemann SF. Swanson GT, et al. Among authors: sakai r. Neuron. 2002 May 16;34(4):589-98. doi: 10.1016/s0896-6273(02)00676-1. Neuron. 2002. PMID: 12062042 Free article.

4

Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors.

Sanders JM, Ito K, Settimo L, Pentikäinen OT, Shoji M, Sasaki M, Johnson MS, Sakai R, Swanson GT. Sanders JM, et al. Among authors: sakai r. J Pharmacol Exp Ther. 2005 Sep;314(3):1068-78. doi: 10.1124/jpet.105.086389. Epub 2005 May 24. J Pharmacol Exp Ther. 2005. PMID: 15914675

5

Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors.

Sanders JM, Pentikäinen OT, Settimo L, Pentikäinen U, Shoji M, Sasaki M, Sakai R, Johnson MS, Swanson GT. Sanders JM, et al. Among authors: sakai r. Mol Pharmacol. 2006 Jun;69(6):1849-60. doi: 10.1124/mol.106.022772. Epub 2006 Mar 14. Mol Pharmacol. 2006. PMID: 16537793

6

Total synthesis and biological evaluation of neodysiherbaine A and analogues.

Shoji M, Akiyama N, Tsubone K, Lash LL, Sanders JM, Swanson GT, Sakai R, Shimamoto K, Oikawa M, Sasaki M. Shoji M, et al. Among authors: sakai r. J Org Chem. 2006 Jul 7;71(14):5208-20. doi: 10.1021/jo0605593. J Org Chem. 2006. PMID: 16808508

7

Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes.

Sasaki M, Tsubone K, Shoji M, Oikawa M, Shimamoto K, Sakai R. Sasaki M, et al. Among authors: sakai r. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5784-7. doi: 10.1016/j.bmcl.2006.08.082. Epub 2006 Sep 1. Bioorg Med Chem Lett. 2006. PMID: 16949819

8

Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors.

Lash LL, Sanders JM, Akiyama N, Shoji M, Postila P, Pentikäinen OT, Sasaki M, Sakai R, Swanson GT. Lash LL, et al. Among authors: sakai r. J Pharmacol Exp Ther. 2008 Feb;324(2):484-96. doi: 10.1124/jpet.107.129890. Epub 2007 Nov 21. J Pharmacol Exp Ther. 2008. PMID: 18032572 Free PMC article.

9

Rapid and efficient synthesis of dysiherbaine and analogues to explore structure-activity relationships.

Sasaki M, Tsubone K, Aoki K, Akiyama N, Shoji M, Oikawa M, Sakai R, Shimamoto K. Sasaki M, et al. Among authors: sakai r. J Org Chem. 2008 Jan 4;73(1):264-73. doi: 10.1021/jo702116c. Epub 2007 Dec 6. J Org Chem. 2008. PMID: 18052390

10

Ligands for ionotropic glutamate receptors.

Swanson GT, Sakai R. Swanson GT, et al. Among authors: sakai r. Prog Mol Subcell Biol. 2009;46:123-57. doi: 10.1007/978-3-540-87895-7_5. Prog Mol Subcell Biol. 2009. PMID: 19184587 Free PMC article. Review.

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