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T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.
Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G, Etzensperger R, Tzartos JS, Kranc K, Sainsbury S, Harlos K, Mellins ED, Palace J, Esiri MM, van der Merwe PA, Jones EY, Fugger L. Harkiolaki M, et al. Among authors: etzensperger r. Immunity. 2009 Mar 20;30(3):348-57. doi: 10.1016/j.immuni.2009.01.009. Immunity. 2009. PMID: 19303388 Free article.
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.
Nika K, Soldani C, Salek M, Paster W, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V, Dushek O, Höfer T, Viola A, Acuto O. Nika K, et al. Among authors: etzensperger r. Immunity. 2010 Jun 25;32(6):766-77. doi: 10.1016/j.immuni.2010.05.011. Epub 2010 Jun 11. Immunity. 2010. PMID: 20541955 Free PMC article.
Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation.
Hong C, Luckey MA, Ligons DL, Waickman AT, Park JY, Kim GY, Keller HR, Etzensperger R, Tai X, Lazarevic V, Feigenbaum L, Catalfamo M, Walsh ST, Park JH. Hong C, et al. Among authors: etzensperger r. Immunity. 2014 Jun 19;40(6):910-23. doi: 10.1016/j.immuni.2014.04.020. Epub 2014 Jun 5. Immunity. 2014. PMID: 24909888 Free PMC article.
18 results