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Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity.
Ciccotosto GD, Tew DJ, Drew SC, Smith DG, Johanssen T, Lal V, Lau TL, Perez K, Curtain CC, Wade JD, Separovic F, Masters CL, Smith JP, Barnham KJ, Cappai R. Ciccotosto GD, et al. Neurobiol Aging. 2011 Feb;32(2):235-48. doi: 10.1016/j.neurobiolaging.2009.02.018. Epub 2009 Mar 25. Neurobiol Aging. 2011. PMID: 19324459
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R. Barnham KJ, et al. Among authors: ciccotosto gd. J Biol Chem. 2003 Oct 31;278(44):42959-65. doi: 10.1074/jbc.M305494200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925530 Free article.
Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.
Tickler AK, Smith DG, Ciccotosto GD, Tew DJ, Curtain CC, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Wade JD, Barnham KJ. Tickler AK, et al. Among authors: ciccotosto gd. J Biol Chem. 2005 Apr 8;280(14):13355-63. doi: 10.1074/jbc.M414178200. Epub 2005 Jan 24. J Biol Chem. 2005. PMID: 15668252 Free article.
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.
Smith DP, Smith DG, Curtain CC, Boas JF, Pilbrow JR, Ciccotosto GD, Lau TL, Tew DJ, Perez K, Wade JD, Bush AI, Drew SC, Separovic F, Masters CL, Cappai R, Barnham KJ. Smith DP, et al. Among authors: ciccotosto gd. J Biol Chem. 2006 Jun 2;281(22):15145-54. doi: 10.1074/jbc.M600417200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595673 Free article.
66 results