Spraggon G - Search Results

1

Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.

Spraggon G, Hornsby M, Shipway A, Tully DC, Bursulaya B, Danahay H, Harris JL, Lesley SA. Spraggon G, et al. Protein Sci. 2009 May;18(5):1081-94. doi: 10.1002/pro.118. Protein Sci. 2009. PMID: 19388054 Free PMC article.

2

Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.

Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A, Schumacher AM, Danahay H, Harris JL. Tully DC, et al. Among authors: spraggon g. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5895-9. doi: 10.1016/j.bmcl.2008.08.029. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18752942

3

Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B.

Chamberlain PP, Sandberg ML, Sauer K, Cooke MP, Lesley SA, Spraggon G. Chamberlain PP, et al. Among authors: spraggon g. Biochemistry. 2005 Nov 8;44(44):14486-93. doi: 10.1021/bi051256q. Biochemistry. 2005. PMID: 16262249

4

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity.

Li J, Tumanut C, Gavigan JA, Huang WJ, Hampton EN, Tumanut R, Suen KF, Trauger JW, Spraggon G, Lesley SA, Liau G, Yowe D, Harris JL. Li J, et al. Among authors: spraggon g. Biochem J. 2007 Sep 1;406(2):203-7. doi: 10.1042/BJ20070664. Biochem J. 2007. PMID: 17608623 Free PMC article.

5

The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.

Hampton EN, Knuth MW, Li J, Harris JL, Lesley SA, Spraggon G. Hampton EN, et al. Among authors: spraggon g. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14604-9. doi: 10.1073/pnas.0703402104. Epub 2007 Sep 5. Proc Natl Acad Sci U S A. 2007. PMID: 17804797 Free PMC article.

6

Crystal structure of human Pus10, a novel pseudouridine synthase.

McCleverty CJ, Hornsby M, Spraggon G, Kreusch A. McCleverty CJ, et al. Among authors: spraggon g. J Mol Biol. 2007 Nov 9;373(5):1243-54. doi: 10.1016/j.jmb.2007.08.053. Epub 2007 Aug 29. J Mol Biol. 2007. PMID: 17900615

7

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Lee CC, Jia Y, Li N, Sun X, Ng K, Ambing E, Gao MY, Hua S, Chen C, Kim S, Michellys PY, Lesley SA, Harris JL, Spraggon G. Lee CC, et al. Among authors: spraggon g. Biochem J. 2010 Sep 15;430(3):425-37. doi: 10.1042/BJ20100609. Biochem J. 2010. PMID: 20632993

8

Crystal structure of a two-subunit TrkA octameric gating ring assembly.

Deller MC, Johnson HA, Miller MD, Spraggon G, Elsliger MA, Wilson IA, Lesley SA. Deller MC, et al. Among authors: spraggon g. PLoS One. 2015 Mar 31;10(3):e0122512. doi: 10.1371/journal.pone.0122512. eCollection 2015. PLoS One. 2015. PMID: 25826626 Free PMC article.

9

On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.

Spraggon G, Pantazatos D, Klock HE, Wilson IA, Woods VL Jr, Lesley SA. Spraggon G, et al. Protein Sci. 2004 Dec;13(12):3187-99. doi: 10.1110/ps.04939904. Protein Sci. 2004. PMID: 15557262 Free PMC article.

10

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.

Patterson AW, Wood WJ, Hornsby M, Lesley S, Spraggon G, Ellman JA. Patterson AW, et al. Among authors: spraggon g. J Med Chem. 2006 Oct 19;49(21):6298-307. doi: 10.1021/jm060701s. J Med Chem. 2006. PMID: 17034136

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