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The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.
Hernlund E, Olofsson MH, Fayad W, Fryknäs M, Lesiak-Mieczkowska K, Zhang X, Brnjic S, Schmidt V, D'Arcy P, Sjöblom T, De Milito A, Larsson R, Linder S. Hernlund E, et al. Among authors: brnjic s. Eur J Cancer. 2012 Feb;48(3):396-406. doi: 10.1016/j.ejca.2011.11.013. Epub 2011 Dec 7. Eur J Cancer. 2012. PMID: 22154651
Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment.
Gullbo J, Fryknäs M, Rickardson L, Darcy P, Hägg M, Wickström M, Hassan S, Westman G, Brnjic S, Nygren P, Linder S, Larsson R. Gullbo J, et al. Among authors: brnjic s. Biochem Pharmacol. 2011 Jul 15;82(2):139-47. doi: 10.1016/j.bcp.2011.04.003. Epub 2011 Apr 22. Biochem Pharmacol. 2011. PMID: 21531212 Free article.
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