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Page 1
Structural mechanisms of inactivation in scabies mite serine protease paralogues.
Fischer K, Langendorf CG, Irving JA, Reynolds S, Willis C, Beckham S, Law RH, Yang S, Bashtannyk-Puhalovich TA, McGowan S, Whisstock JC, Pike RN, Kemp DJ, Buckle AM. Fischer K, et al. Among authors: bashtannyk puhalovich ta. J Mol Biol. 2009 Jul 24;390(4):635-45. doi: 10.1016/j.jmb.2009.04.082. Epub 2009 May 7. J Mol Biol. 2009. PMID: 19427318
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC. Law RH, et al. Among authors: bashtannyk puhalovich ta. J Biol Chem. 2005 Jun 10;280(23):22356-64. doi: 10.1074/jbc.M412043200. Epub 2005 Mar 10. J Biol Chem. 2005. PMID: 15760906 Free article.
X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan WT, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN, Whisstock JC. McGowan S, et al. Among authors: bashtannyk puhalovich ta. EMBO J. 2006 Jul 12;25(13):3144-55. doi: 10.1038/sj.emboj.7601201. Epub 2006 Jun 29. EMBO J. 2006. PMID: 16810322 Free PMC article.
A common fold mediates vertebrate defense and bacterial attack.
Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC. Rosado CJ, et al. Among authors: bashtannyk puhalovich ta. Science. 2007 Sep 14;317(5844):1548-51. doi: 10.1126/science.1144706. Epub 2007 Aug 23. Science. 2007. PMID: 17717151
Conformational change in the chromatin remodelling protein MENT.
Ong PC, Golding SJ, Pearce MC, Irving JA, Grigoryev SA, Pike D, Langendorf CG, Bashtannyk-Puhalovich TA, Bottomley SP, Whisstock JC, Pike RN, McGowan S. Ong PC, et al. Among authors: bashtannyk puhalovich ta. PLoS One. 2009;4(3):e4727. doi: 10.1371/journal.pone.0004727. Epub 2009 Mar 6. PLoS One. 2009. PMID: 19266095 Free PMC article.
Structure of granzyme C reveals an unusual mechanism of protease autoinhibition.
Kaiserman D, Buckle AM, Van Damme P, Irving JA, Law RH, Matthews AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson P, Vandekerckhove J, Gevaert K, Whisstock JC, Bird PI. Kaiserman D, et al. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5587-92. doi: 10.1073/pnas.0811968106. Epub 2009 Mar 19. Proc Natl Acad Sci U S A. 2009. PMID: 19299505 Free PMC article.
Fragment-based and structure-guided discovery of perforin inhibitors.
Jose J, Law RHP, Leung EWW, Wai DCC, Akhlaghi H, Chandrashekaran IR, Caradoc-Davies TT, Voskoboinik I, Feutrill J, Middlemiss D, Jeevarajah D, Bashtannyk-Puhalovich T, Giddens AC, Lee TW, Jamieson SMF, Trapani JA, Whisstock JC, Spicer JA, Norton RS. Jose J, et al. Eur J Med Chem. 2023 Dec 5;261:115786. doi: 10.1016/j.ejmech.2023.115786. Epub 2023 Sep 1. Eur J Med Chem. 2023. PMID: 37716187 Free article.