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Page 1
N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.
Ladduwahetty T, Baker R, Cascieri MA, Chambers MS, Haworth K, Keown LE, MacIntyre DE, Metzger JM, Owen S, Rycroft W, Sadowski S, Seward EM, Shepheard SL, Swain CJ, Tattersall FD, Watt AP, Williamson DW, Hargreaves RJ. Ladduwahetty T, et al. Among authors: keown le. J Med Chem. 1996 Jul 19;39(15):2907-14. doi: 10.1021/jm9506534. J Med Chem. 1996. PMID: 8709125
An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists.
Lewis RT, Ladduwahetty T, Merchant KJ, Keown LE, Hitzel L, Verrier H, Stevenson GI, MacLeod AM. Lewis RT, et al. Among authors: keown le. J Org Chem. 2000 Apr 21;65(8):2615-8. doi: 10.1021/jo9918246. J Org Chem. 2000. PMID: 10789488 No abstract available.
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1.
Paterson I, Chen DY, Coster MJ, Aceña JL, Bach J, Gibson KR, Keown LE, Oballa RM, Trieselmann T, Wallace DJ, Hodgson AP, Norcross RD. Paterson I, et al. Among authors: keown le. Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4055-4060. doi: 10.1002/1521-3773(20011105)40:21<4055::AID-ANIE4055>3.0.CO;2-H. Angew Chem Int Ed Engl. 2001. PMID: 29712249
Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.
Paterson I, Chen DY, Coster MJ, Aceña JL, Bach J, Gibson KR, Keown LE, Oballa RM, Trieselmann T, Wallace DJ, Hodgson AP, Norcross RD. Paterson I, et al. Among authors: keown le. Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4055-4060. Angew Chem Int Ed Engl. 2001. PMID: 12404491 No abstract available.