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Page 1
Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Pu J, Kreft AF, Aschmies SH, Atchison KP, Berkowitz J, Caggiano TJ, Chlenov M, Diamantidis G, Harrison BL, Hu Y, Huryn D, Steven Jacobsen J, Jin M, Lipinski K, Lu P, Martone RL, Morris K, Sonnenberg-Reines J, Riddell DR, Sabalski J, Sun SC, Wagner E, Wang Y, Xu Z, Zhou H, Resnick L. Pu J, et al. Among authors: morris k. Bioorg Med Chem. 2009 Jul 1;17(13):4708-17. doi: 10.1016/j.bmc.2009.04.052. Epub 2009 May 3. Bioorg Med Chem. 2009. PMID: 19443228
Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability.
Malamas MS, Robichaud A, Erdei J, Quagliato D, Solvibile W, Zhou P, Morris K, Turner J, Wagner E, Fan K, Olland A, Jacobsen S, Reinhart P, Riddell D, Pangalos M. Malamas MS, et al. Among authors: morris k. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6597-605. doi: 10.1016/j.bmcl.2010.09.029. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20880704
Pulvinones as bacterial cell wall biosynthesis inhibitors.
Antane S, Caufield CE, Hu W, Keeney D, Labthavikul P, Morris K, Naughton SM, Petersen PJ, Rasmussen BA, Singh G, Yang Y. Antane S, et al. Among authors: morris k. Bioorg Med Chem Lett. 2006 Jan 1;16(1):176-80. doi: 10.1016/j.bmcl.2005.09.021. Epub 2005 Oct 10. Bioorg Med Chem Lett. 2006. PMID: 16216496
PDE4 inhibitors: new xanthine analogues.
Montana JG, Cooper N, Dyke HJ, Gowers L, Gregory JP, Hellewell PG, Miotla J, Morris K, Naylor R, Tuladhar B, Warneck JB. Montana JG, et al. Among authors: morris k. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2925-30. doi: 10.1016/s0960-894x(98)00524-1. Bioorg Med Chem Lett. 1998. PMID: 9873649
Discovery and Optimization of Glucose Uptake Inhibitors.
Liu KG, Kim JI, Olszewski K, Barsotti AM, Morris K, Lamarque C, Yu X, Gaffney J, Feng XJ, Patel JP, Poyurovsky MV. Liu KG, et al. Among authors: morris k. J Med Chem. 2020 May 28;63(10):5201-5211. doi: 10.1021/acs.jmedchem.9b02153. Epub 2020 May 8. J Med Chem. 2020. PMID: 32282207
Naphthyl tetronic acids as multi-target inhibitors of bacterial peptidoglycan biosynthesis.
Mansour TS, Caufield CE, Rasmussen B, Chopra R, Krishnamurthy G, Morris KM, Svenson K, Bard J, Smeltzer C, Naughton S, Antane S, Yang Y, Severin A, Quagliato D, Petersen PJ, Singh G. Mansour TS, et al. Among authors: morris km. ChemMedChem. 2007 Oct;2(10):1414-7. doi: 10.1002/cmdc.200700094. ChemMedChem. 2007. PMID: 17600795 No abstract available.
Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.
Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV. Olszewski K, et al. Among authors: morris k. Cell Chem Biol. 2022 Mar 17;29(3):423-435.e10. doi: 10.1016/j.chembiol.2021.10.007. Epub 2021 Oct 28. Cell Chem Biol. 2022. PMID: 34715056 Free article.
Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disease.
Handsaker RE, Kashin S, Reed NM, Tan S, Lee WS, McDonald TM, Morris K, Kamitaki N, Mullally CD, Morakabati NR, Goldman M, Lind G, Kohli R, Lawton E, Hogan M, Ichihara K, Berretta S, McCarroll SA. Handsaker RE, et al. Among authors: morris k. Cell. 2025 Jan 14:S0092-8674(24)01379-5. doi: 10.1016/j.cell.2024.11.038. Online ahead of print. Cell. 2025. PMID: 39824182 Free article.
Sense the Wave Coming?
Morris KL, Ravichandran A. Morris KL, et al. J Card Fail. 2025 Jan 14:S1071-9164(25)00005-3. doi: 10.1016/j.cardfail.2025.01.001. Online ahead of print. J Card Fail. 2025. PMID: 39818265 No abstract available.
2,090 results