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A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, Arai H. Fujiwara H, et al. Among authors: maeda s. J Neurochem. 2009 Jun;109(6):1648-57. doi: 10.1111/j.1471-4159.2009.06069.x. Epub 2009 May 7. J Neurochem. 2009. PMID: 19457098 Free article.
Aluminum induces tau aggregation in vitro but not in vivo.
Mizoroki T, Meshitsuka S, Maeda S, Murayama M, Sahara N, Takashima A. Mizoroki T, et al. Among authors: maeda s. J Alzheimers Dis. 2007 Jul;11(4):419-27. doi: 10.3233/jad-2007-11401. J Alzheimers Dis. 2007. PMID: 17656819
Tau Oligomers.
Maeda S, Takashima A. Maeda S, et al. Adv Exp Med Biol. 2019;1184:373-380. doi: 10.1007/978-981-32-9358-8_27. Adv Exp Med Biol. 2019. PMID: 32096050 Review.
Granular tau oligomers as intermediates of tau filaments.
Maeda S, Sahara N, Saito Y, Murayama M, Yoshiike Y, Kim H, Miyasaka T, Murayama S, Ikai A, Takashima A. Maeda S, et al. Biochemistry. 2007 Mar 27;46(12):3856-61. doi: 10.1021/bi061359o. Epub 2007 Mar 6. Biochemistry. 2007. PMID: 17338548
4,123 results