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A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, Arai H. Fujiwara H, et al. Among authors: tabuchi m. J Neurochem. 2009 Jun;109(6):1648-57. doi: 10.1111/j.1471-4159.2009.06069.x. Epub 2009 May 7. J Neurochem. 2009. PMID: 19457098 Free article.
Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice.
Fujiwara H, Takayama S, Iwasaki K, Tabuchi M, Yamaguchi T, Sekiguchi K, Ikarashi Y, Kudo Y, Kase Y, Arai H, Yaegashi N. Fujiwara H, et al. Among authors: tabuchi m. Neuroscience. 2011 Apr 28;180:305-13. doi: 10.1016/j.neuroscience.2011.01.064. Epub 2011 Feb 12. Neuroscience. 2011. PMID: 21303686
Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan.
Nishi A, Yamaguchi T, Sekiguchi K, Imamura S, Tabuchi M, Kanno H, Nakai Y, Hashimoto K, Ikarashi Y, Kase Y. Nishi A, et al. Among authors: tabuchi m. Neuroscience. 2012 Apr 5;207:124-36. doi: 10.1016/j.neuroscience.2012.01.037. Epub 2012 Jan 24. Neuroscience. 2012. PMID: 22314317
Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometry.
Kushida H, Fukutake M, Tabuchi M, Katsuhara T, Nishimura H, Ikarashi Y, Kanitani M, Kase Y. Kushida H, et al. Among authors: tabuchi m. Biomed Chromatogr. 2013 Dec;27(12):1647-56. doi: 10.1002/bmc.2974. Epub 2013 Jul 1. Biomed Chromatogr. 2013. PMID: 23813572
415 results