Guedes RC - Search Results

1

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.

Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J, Rosenthal PJ, Moreira R, Lopes F. Rodrigues T, et al. Among authors: guedes rc. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3476-80. doi: 10.1016/j.bmcl.2009.05.017. Epub 2009 May 9. Bioorg Med Chem Lett. 2009. PMID: 19467600

2

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases.

Iley J, Moreira R, Martins L, Guedes RC, Soares CM. Iley J, et al. Among authors: guedes rc. Bioorg Med Chem Lett. 2006 May 15;16(10):2738-41. doi: 10.1016/j.bmcl.2006.02.007. Epub 2006 Feb 28. Bioorg Med Chem Lett. 2006. PMID: 16503139

3

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum.

Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ. Valente C, et al. Among authors: guedes rc. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4115-9. doi: 10.1016/j.bmcl.2006.04.079. Epub 2006 May 12. Bioorg Med Chem Lett. 2006. PMID: 16697641

4

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.

Valente C, Moreira R, Guedes RC, Iley J, Jaffar M, Douglas KT. Valente C, et al. Among authors: guedes rc. Bioorg Med Chem. 2007 Aug 1;15(15):5340-50. doi: 10.1016/j.bmc.2007.04.068. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17532221

5

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors.

Mulchande J, Guedes RC, Tsang WY, Page MI, Moreira R, Iley J. Mulchande J, et al. Among authors: guedes rc. J Med Chem. 2008 Mar 27;51(6):1783-90. doi: 10.1021/jm701257h. Epub 2008 Feb 22. J Med Chem. 2008. PMID: 18290604

6

Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design.

Rodrigues T, Moreira R, Guedes RC, Iley J, Lopes F. Rodrigues T, et al. Among authors: guedes rc. Arch Pharm (Weinheim). 2008 Jun;341(6):344-50. doi: 10.1002/ardp.200700250. Arch Pharm (Weinheim). 2008. PMID: 18442019

7

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

Mulchande J, Oliveira R, Carrasco M, Gouveia L, Guedes RC, Iley J, Moreira R. Mulchande J, et al. Among authors: guedes rc. J Med Chem. 2010 Jan 14;53(1):241-53. doi: 10.1021/jm901082k. J Med Chem. 2010. PMID: 19904934

8

Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.

Newton AS, Glória PM, Gonçalves LM, dos Santos DJ, Moreira R, Guedes RC, Santos MM. Newton AS, et al. Among authors: guedes rc. Eur J Med Chem. 2010 Sep;45(9):3858-63. doi: 10.1016/j.ejmech.2010.05.039. Epub 2010 May 24. Eur J Med Chem. 2010. PMID: 20541849

9

Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.

Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A, Rosenthal PJ, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. Gibbons P, et al. Among authors: guedes rc. J Med Chem. 2010 Nov 25;53(22):8202-6. doi: 10.1021/jm1009567. Epub 2010 Oct 27. J Med Chem. 2010. PMID: 20979352

10

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.

Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. Lavrado J, et al. Among authors: guedes rc. J Med Chem. 2011 Feb 10;54(3):734-50. doi: 10.1021/jm101383f. Epub 2011 Jan 5. J Med Chem. 2011. PMID: 21207937

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