Hochman JH - Search Results

1

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys.

Tang C, Kuo Y, Pudvah NT, Ellis JD, Michener MS, Egbertson M, Graham SL, Cook JJ, Hochman JH, Prueksaritanont T. Tang C, et al. Among authors: hochman jh. Biochem Pharmacol. 2009 Sep 15;78(6):642-7. doi: 10.1016/j.bcp.2009.05.026. Epub 2009 May 27. Biochem Pharmacol. 2009. PMID: 19481060

2

Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin.

Hochman JH, Pudvah N, Qiu J, Yamazaki M, Tang C, Lin JH, Prueksaritanont T. Hochman JH, et al. Pharm Res. 2004 Sep;21(9):1686-91. doi: 10.1023/b:pham.0000041466.84653.8c. Pharm Res. 2004. PMID: 15497697

3

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.

Sankaranarayanan S, Holahan MA, Colussi D, Crouthamel MC, Devanarayan V, Ellis J, Espeseth A, Gates AT, Graham SL, Gregro AR, Hazuda D, Hochman JH, Holloway K, Jin L, Kahana J, Lai MT, Lineberger J, McGaughey G, Moore KP, Nantermet P, Pietrak B, Price EA, Rajapakse H, Stauffer S, Steinbeiser MA, Seabrook G, Selnick HG, Shi XP, Stanton MG, Swestock J, Tugusheva K, Tyler KX, Vacca JP, Wong J, Wu G, Xu M, Cook JJ, Simon AJ. Sankaranarayanan S, et al. Among authors: hochman jh. J Pharmacol Exp Ther. 2009 Jan;328(1):131-40. doi: 10.1124/jpet.108.143628. Epub 2008 Oct 14. J Pharmacol Exp Ther. 2009. PMID: 18854490

4

Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein.

Prueksaritanont T, Meng Y, Ma B, Leppert P, Hochman J, Tang C, Perkins J, Zrada M, Meissner R, Duggan ME, Lin JH. Prueksaritanont T, et al. Among authors: hochman j. Xenobiotica. 2002 Mar;32(3):207-20. doi: 10.1080/00498250110094403. Xenobiotica. 2002. PMID: 11958560

5

P-glycoprotein-mediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4.

Hochman JH, Chiba M, Yamazaki M, Tang C, Lin JH. Hochman JH, et al. J Pharmacol Exp Ther. 2001 Jul;298(1):323-30. J Pharmacol Exp Ther. 2001. PMID: 11408558

6

Renal elimination of a novel and potent alphavbeta3 integrin antagonist in animals.

Prueksaritanont T, Hochman JH, Meng Y, Pudvah NT, Barrish A, Ma B, Yamazaki M, Fernandez-Metzler C, Lin JH. Prueksaritanont T, et al. Among authors: hochman jh. Xenobiotica. 2004 Nov-Dec;34(11-12):1059-74. doi: 10.1080/00498250400015277. Xenobiotica. 2004. PMID: 15801548

7

Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport.

Yamazaki M, Li B, Louie SW, Pudvah NT, Stocco R, Wong W, Abramovitz M, Demartis A, Laufer R, Hochman JH, Prueksaritanont T, Lin JH. Yamazaki M, et al. Among authors: hochman jh. Xenobiotica. 2005 Jul;35(7):737-53. doi: 10.1080/00498250500136676. Xenobiotica. 2005. PMID: 16316932

8

Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2.

Mei Q, Richards K, Strong-Basalyga K, Fauty SE, Taylor A, Yamazaki M, Prueksaritanont T, Lin JH, Hochman J. Mei Q, et al. Among authors: hochman j. J Pharm Sci. 2004 Oct;93(10):2488-96. doi: 10.1002/jps.20102. J Pharm Sci. 2004. PMID: 15349958

9

Drug-drug interactions related to altered absorption and plasma protein binding: theoretical and regulatory considerations, and an industry perspective.

Hochman J, Tang C, Prueksaritanont T. Hochman J, et al. J Pharm Sci. 2015 Mar;104(3):916-29. doi: 10.1002/jps.24306. Epub 2014 Dec 30. J Pharm Sci. 2015. PMID: 25557998 Review.

10

Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors.

Moore KP, Zhu H, Rajapakse HA, McGaughey GB, Colussi D, Price EA, Sankaranarayanan S, Simon AJ, Pudvah NT, Hochman JH, Allison T, Munshi SK, Graham SL, Vacca JP, Nantermet PG. Moore KP, et al. Among authors: hochman jh. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5831-5. doi: 10.1016/j.bmcl.2007.08.040. Epub 2007 Aug 23. Bioorg Med Chem Lett. 2007. PMID: 17827011

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