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A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V. Scott L, et al. Among authors: pape w. Toxicol In Vitro. 2010 Feb;24(1):1-9. doi: 10.1016/j.tiv.2009.05.019. Epub 2009 May 31. Toxicol In Vitro. 2010. PMID: 19490935 Review.
A summary report of the COLIPA international validation study on alternatives to the draize rabbit eye irritation test.
Brantom PG, Bruner LH, Chamberlain M, De Silva O, Dupuis J, Earl LK, Lovell DP, Pape WJ, Uttley M, Bagley DM, Baker FW, Bracher M, Courtellemont P, Declercq L, Freeman S, Steiling W, Walker AP, Carr GJ, Dami N, Thomas G, Harbell J, Jones PA, Pfannenbecker U, Southee JA, Tcheng M, Argembeaux H, Castelli D, Clothier R, Esdaile DJ, Itigaki H, Jung K, Kasai Y, Kojima H, Kristen U, Larnicol M, Lewis RW, Marenus K, Moreno O, Peterson A, Rasmussen ES, Robles C, Stern M. Brantom PG, et al. Among authors: pape wj. Toxicol In Vitro. 1997 Feb-Apr;11(1-2):141-79. doi: 10.1016/s0887-2333(96)00069-0. Toxicol In Vitro. 1997. PMID: 20654303
The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test.
Spielmann H, Balls M, Dupuis J, Pape WJ, Pechovitch G, de Silva O, Holzhütter HG, Clothier R, Desolle P, Gerberick F, Liebsch M, Lovell WW, Maurer T, Pfannenbecker U, Potthast JM, Csato M, Sladowski D, Steiling W, Brantom P. Spielmann H, et al. Among authors: pape wj. Toxicol In Vitro. 1998 Jun 1;12(3):305-27. doi: 10.1016/s0887-2333(98)00006-x. Toxicol In Vitro. 1998. PMID: 20654413
65 results