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A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V. Scott L, et al. Among authors: seaman c. Toxicol In Vitro. 2010 Feb;24(1):1-9. doi: 10.1016/j.tiv.2009.05.019. Epub 2009 May 31. Toxicol In Vitro. 2010. PMID: 19490935 Review.
Guiding principles for the implementation of non-animal safety assessment approaches for cosmetics: skin sensitisation.
Goebel C, Aeby P, Ade N, Alépée N, Aptula A, Araki D, Dufour E, Gilmour N, Hibatallah J, Keller D, Kern P, Kirst A, Marrec-Fairley M, Maxwell G, Rowland J, Safford B, Schellauf F, Schepky A, Seaman C, Teichert T, Tessier N, Teissier S, Weltzien HU, Winkler P, Scheel J. Goebel C, et al. Among authors: seaman c. Regul Toxicol Pharmacol. 2012 Jun;63(1):40-52. doi: 10.1016/j.yrtph.2012.02.007. Epub 2012 Feb 21. Regul Toxicol Pharmacol. 2012. PMID: 22374415 Free article.
Using default methodologies to derive an acceptable daily exposure (ADE).
Faria EC, Bercu JP, Dolan DG, Morinello EJ, Pecquet AM, Seaman C, Sehner C, Weideman PA. Faria EC, et al. Among authors: seaman c. Regul Toxicol Pharmacol. 2016 Aug;79 Suppl 1:S28-38. doi: 10.1016/j.yrtph.2016.05.026. Epub 2016 May 24. Regul Toxicol Pharmacol. 2016. PMID: 27233926 Review.
LLC-RK1 cell screening test for nephrotoxicity.
White DJ, Seaman C. White DJ, et al. Among authors: seaman c. Methods Mol Biol. 1995;43:11-6. doi: 10.1385/0-89603-282-5:11. Methods Mol Biol. 1995. PMID: 7550638 No abstract available.
An early economic analysis of medical cannabis for the treatment of chronic pain.
Marrinan S, Schlag AK, Lynskey M, Seaman C, Barnes MP, Morgan-Giles M, Nutt D. Marrinan S, et al. Among authors: seaman c. Expert Rev Pharmacoecon Outcomes Res. 2025 Jan;25(1):39-52. doi: 10.1080/14737167.2024.2412248. Epub 2024 Oct 16. Expert Rev Pharmacoecon Outcomes Res. 2025. PMID: 39415537
158 results