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[Clinical effects of combination therapy with cefozopran and tobramycin for severe infections in patients with hematologic diseases].
Toyama K, Yaguchi M, Uchida Y, Suzuki K, Sawanobori M, Ikeda Y, Matsuoka S, Wakasugi K, Furuya T, Oshimi K, Kawamata N, Kikuchi M, Murakami H, Tsuruoka N, Tomoyasu S, Kawaguchi M, Hirosawa S, Yamamoto K, Shirota T, Harada Y, Dan K, Yamada T, Kawano K, Onozawa Y, Takeuchi J, et al. Toyama K, et al. Among authors: yamamoto k. Jpn J Antibiot. 1999 Feb;52(2):153-61. Jpn J Antibiot. 1999. PMID: 10221180 Clinical Trial. Japanese.
Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor (CAG regimen) for previously treated patients with relapsed or primary resistant acute myelogenous leukemia (AML) and previously untreated elderly patients with AML, secondary AML, and refractory anemia with excess blasts in transformation.
Saito K, Nakamura Y, Aoyagi M, Waga K, Yamamoto K, Aoyagi A, Inoue F, Nakamura Y, Arai Y, Tadokoro J, Handa T, Tsurumi S, Arai H, Kawagoe Y, Gunnji H, Kitsukawa Y, Takahashi W, Furusawa S. Saito K, et al. Among authors: yamamoto k. Int J Hematol. 2000 Apr;71(3):238-44. Int J Hematol. 2000. PMID: 10846828
Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: significant roles of total body irradiation and chronic graft-versus-host disease.
Yanada M, Naoe T, Iida H, Sakamaki H, Sakura T, Kanamori H, Kodera Y, Okamoto S, Kanda Y, Sao H, Asai O, Nakai K, Maruta A, Kishi K, Furukawa T, Atsuta Y, Yamamoto K, Tanaka J, Takahashi S. Yanada M, et al. Among authors: yamamoto k. Bone Marrow Transplant. 2005 Nov;36(10):867-72. doi: 10.1038/sj.bmt.1705148. Bone Marrow Transplant. 2005. PMID: 16113659
(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays showed a lack of toxicity of ganciclovir (GCV), C.OXTs, and their derivatives, to TaY(OK) cells at 1 microM. Therefore we compared the antiviral potencies of these drugs at 1 microM by monitoring the viral loads produced during a 1-day period during the course of the drug treatment. Among the drugs tested, 3'-fluorocarbocyclic oxetanocin A (3'F-C.OXT-A) was the most effective for inhibiting the virus production, and at concentrations ranging from 0.5 microM to 10 microM, the inhibition of the viral production was dose-dependent. A comparison of the chemical structures of the derivatives with that of C.OXT-A, which is the parental molecule, suggested that the 3'-fluorine-modification might account for the higher anti-HHV-6 activity and lower cytotoxicity.
Wang P, Abe K, Ojima T, Ohyashiki JH, Satoh H, Maruyama T, Nagata H, Tanaka H, Yamamoto K. Wang P, et al. Among authors: yamamoto k. Microbiol Immunol. 2001;45(6):457-66. doi: 10.1111/j.1348-0421.2001.tb02645.x. Microbiol Immunol. 2001. PMID: 11497221 Free article.
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