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Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity.
Harmeier A, Wozny C, Rost BR, Munter LM, Hua H, Georgiev O, Beyermann M, Hildebrand PW, Weise C, Schaffner W, Schmitz D, Multhaup G. Harmeier A, et al. Among authors: hildebrand pw. J Neurosci. 2009 Jun 10;29(23):7582-90. doi: 10.1523/JNEUROSCI.1336-09.2009. J Neurosci. 2009. PMID: 19515926 Free PMC article.
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.
Munter LM, Botev A, Richter L, Hildebrand PW, Althoff V, Weise C, Kaden D, Multhaup G. Munter LM, et al. Among authors: hildebrand pw. J Biol Chem. 2010 Jul 9;285(28):21636-43. doi: 10.1074/jbc.M109.088005. Epub 2010 May 7. J Biol Chem. 2010. PMID: 20452985 Free PMC article.
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G. Richter L, et al. Among authors: hildebrand pw. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2. Proc Natl Acad Sci U S A. 2010. PMID: 20679249 Free PMC article.
Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers.
Kaden D, Harmeier A, Weise C, Munter LM, Althoff V, Rost BR, Hildebrand PW, Schmitz D, Schaefer M, Lurz R, Skodda S, Yamamoto R, Arlt S, Finckh U, Multhaup G. Kaden D, et al. Among authors: hildebrand pw. EMBO Mol Med. 2012 Jul;4(7):647-59. doi: 10.1002/emmm.201200239. Epub 2012 Apr 19. EMBO Mol Med. 2012. PMID: 22514144 Free PMC article.
Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.
Barucker C, Bittner HJ, Chang PK, Cameron S, Hancock MA, Liebsch F, Hossain S, Harmeier A, Shaw H, Charron FM, Gensler M, Dembny P, Zhuang W, Schmitz D, Rabe JP, Rao Y, Lurz R, Hildebrand PW, McKinney RA, Multhaup G. Barucker C, et al. Among authors: hildebrand pw. Sci Rep. 2015 Oct 29;5:15410. doi: 10.1038/srep15410. Sci Rep. 2015. PMID: 26510576 Free PMC article.
84 results