Conley J - Search Results

1

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).

Tremblay MR, Lescarbeau A, Grogan MJ, Tan E, Lin G, Austad BC, Yu LC, Behnke ML, Nair SJ, Hagel M, White K, Conley J, Manna JD, Alvarez-Diez TM, Hoyt J, Woodward CN, Sydor JR, Pink M, MacDougall J, Campbell MJ, Cushing J, Ferguson J, Curtis MS, McGovern K, Read MA, Palombella VJ, Adams J, Castro AC. Tremblay MR, et al. Among authors: conley j. J Med Chem. 2009 Jul 23;52(14):4400-18. doi: 10.1021/jm900305z. J Med Chem. 2009. PMID: 19522463

2

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL. Peluso MO, et al. PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534. eCollection 2014. PLoS One. 2014. PMID: 24608250 Free PMC article.

3

Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.

Liu T, Nair SJ, Lescarbeau A, Belani J, Peluso S, Conley J, Tillotson B, O'Hearn P, Smith S, Slocum K, West K, Helble J, Douglas M, Bahadoor A, Ali J, McGovern K, Fritz C, Palombella VJ, Wylie A, Castro AC, Tremblay MR. Liu T, et al. Among authors: conley j. J Med Chem. 2012 Oct 25;55(20):8859-78. doi: 10.1021/jm3011542. Epub 2012 Oct 12. J Med Chem. 2012. PMID: 23025805

4

IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.

Nayar R, Schutten E, Jangalwe S, Durost PA, Kenney LL, Conley JM, Daniels K, Brehm MA, Welsh RM, Berg LJ. Nayar R, et al. Among authors: conley jm. PLoS One. 2015 Dec 29;10(12):e0144826. doi: 10.1371/journal.pone.0144826. eCollection 2015. PLoS One. 2015. PMID: 26714260 Free PMC article.

5

T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells.

Conley JM, Gallagher MP, Berg LJ. Conley JM, et al. Front Immunol. 2016 Feb 29;7:76. doi: 10.3389/fimmu.2016.00076. eCollection 2016. Front Immunol. 2016. PMID: 26973653 Free PMC article. Review.

6

Peptide Antigen Concentration Modulates Digital NFAT1 Activation in Primary Mouse Naive CD8⁺ T Cells as Measured by Flow Cytometry of Isolated Cell Nuclei.

Gallagher MP, Conley JM, Berg LJ. Gallagher MP, et al. Among authors: conley jm. Immunohorizons. 2018 Aug;2(7):208-215. doi: 10.4049/immunohorizons.1800032. Immunohorizons. 2018. PMID: 30221251 Free PMC article.

7

Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength.

Conley JM, Gallagher MP, Rao A, Berg LJ. Conley JM, et al. J Immunol. 2020 Jul 15;205(2):335-345. doi: 10.4049/jimmunol.1900853. Epub 2020 Jun 3. J Immunol. 2020. PMID: 32493815 Free PMC article.

8

Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.

Gallagher MP, Conley JM, Vangala P, Garber M, Reboldi A, Berg LJ. Gallagher MP, et al. Among authors: conley jm. Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):e2025825118. doi: 10.1073/pnas.2025825118. Proc Natl Acad Sci U S A. 2021. PMID: 34452995 Free PMC article.

9

Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.

Andreotti AH, Joseph RE, Conley JM, Iwasa J, Berg LJ. Andreotti AH, et al. Among authors: conley jm. Annu Rev Immunol. 2018 Apr 26;36:549-578. doi: 10.1146/annurev-immunol-042617-053344. Annu Rev Immunol. 2018. PMID: 29677469

10

TCR signaling: it's all about the numbers.

Conley JM, Berg LJ. Conley JM, et al. Nat Immunol. 2019 Nov;20(11):1415-1416. doi: 10.1038/s41590-019-0520-0. Nat Immunol. 2019. PMID: 31591572 Free PMC article.

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