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Page 1
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Tremblay MR, Lescarbeau A, Grogan MJ, Tan E, Lin G, Austad BC, Yu LC, Behnke ML, Nair SJ, Hagel M, White K, Conley J, Manna JD, Alvarez-Diez TM, Hoyt J, Woodward CN, Sydor JR, Pink M, MacDougall J, Campbell MJ, Cushing J, Ferguson J, Curtis MS, McGovern K, Read MA, Palombella VJ, Adams J, Castro AC. Tremblay MR, et al. Among authors: macdougall j. J Med Chem. 2009 Jul 23;52(14):4400-18. doi: 10.1021/jm900305z. J Med Chem. 2009. PMID: 19522463
PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.
Winkler DG, Faia KL, DiNitto JP, Ali JA, White KF, Brophy EE, Pink MM, Proctor JL, Lussier J, Martin CM, Hoyt JG, Tillotson B, Murphy EL, Lim AR, Thomas BD, Macdougall JR, Ren P, Liu Y, Li LS, Jessen KA, Fritz CC, Dunbar JL, Porter JR, Rommel C, Palombella VJ, Changelian PS, Kutok JL. Winkler DG, et al. Among authors: macdougall jr. Chem Biol. 2013 Nov 21;20(11):1364-74. doi: 10.1016/j.chembiol.2013.09.017. Epub 2013 Nov 7. Chem Biol. 2013. PMID: 24211136
Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.
Tillotson B, Slocum K, Coco J, Whitebread N, Thomas B, West KA, MacDougall J, Ge J, Ali JA, Palombella VJ, Normant E, Adams J, Fritz CC. Tillotson B, et al. Among authors: macdougall j. J Biol Chem. 2010 Dec 17;285(51):39835-43. doi: 10.1074/jbc.M110.141580. Epub 2010 Oct 12. J Biol Chem. 2010. PMID: 20940293 Free PMC article.
Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.
McCann CK, Growdon WB, Kulkarni-Datar K, Curley MD, Friel AM, Proctor JL, Sheikh H, Deyneko I, Ferguson JA, Vathipadiekal V, Birrer MJ, Borger DR, Mohapatra G, Zukerberg LR, Foster R, Macdougall JR, Rueda BR. McCann CK, et al. Among authors: macdougall jr. PLoS One. 2011;6(11):e28077. doi: 10.1371/journal.pone.0028077. Epub 2011 Nov 29. PLoS One. 2011. PMID: 22140510 Free PMC article.
An Infrared Dye-Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma.
Kines RC, Varsavsky I, Choudhary S, Bhattacharya D, Spring S, McLaughlin R, Kang SJ, Grossniklaus HE, Vavvas D, Monks S, MacDougall JR, de Los Pinos E, Schiller JT. Kines RC, et al. Among authors: macdougall jr. Mol Cancer Ther. 2018 Feb;17(2):565-574. doi: 10.1158/1535-7163.MCT-17-0953. Epub 2017 Dec 14. Mol Cancer Ther. 2018. PMID: 29242243 Free PMC article.
Treatment parameters modulating regression of human melanoma xenografts by an antibody-drug conjugate (CR011-vcMMAE) targeting GPNMB.
Pollack VA, Alvarez E, Tse KF, Torgov MY, Xie S, Shenoy SG, MacDougall JR, Arrol S, Zhong H, Gerwien RW, Hahne WF, Senter PD, Jeffers ME, Lichenstein HS, LaRochelle WJ. Pollack VA, et al. Among authors: macdougall jr. Cancer Chemother Pharmacol. 2007 Aug;60(3):423-35. doi: 10.1007/s00280-007-0490-z. Epub 2007 Jun 1. Cancer Chemother Pharmacol. 2007. PMID: 17541593
CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL, MacDougall JR, Rastelli L, Herrmann J, Gallo M, Gazit-Bornstein G, Senter PD, Meyer DL, Lichenstein HS, LaRochelle WJ. Tse KF, et al. Among authors: macdougall jr. Clin Cancer Res. 2006 Feb 15;12(4):1373-82. doi: 10.1158/1078-0432.CCR-05-2018. Clin Cancer Res. 2006. PMID: 16489096
354 results