Kienhuis AS - Search Results

1

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13. Toxicol In Vitro. 2009. PMID: 19527782

2

The role of trust in the use of artificial intelligence for chemical risk assessment.

Wassenaar PNH, Minnema J, Vriend J, Peijnenburg WJGM, Pennings JLA, Kienhuis A. Wassenaar PNH, et al. Regul Toxicol Pharmacol. 2024 Mar;148:105589. doi: 10.1016/j.yrtph.2024.105589. Epub 2024 Feb 23. Regul Toxicol Pharmacol. 2024. PMID: 38403009 Free article.

3

The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants.

Staal YCM, Geraets L, Rothen-Rutishauser B, Clift MJD, Braakhuis H, Kienhuis AS, Bos PMJ. Staal YCM, et al. Among authors: kienhuis as. ALTEX. 2024 Jan 9;41(1):91-103. doi: 10.14573/altex.2305311. Epub 2023 Oct 12. ALTEX. 2024. PMID: 37843016 Free article.

4

New Approach Methodologies (NAMs) for ad hoc human health risk assessment of food and non-food products - Proceedings of a workshop.

de Wit L, Hendriks H, van Engelen J, Heusinkveld H, Kienhuis A, Rorije E, Woutersen M, van der Zee M, Jeurissen S. de Wit L, et al. Regul Toxicol Pharmacol. 2024 May;149:105615. doi: 10.1016/j.yrtph.2024.105615. Epub 2024 Mar 28. Regul Toxicol Pharmacol. 2024. PMID: 38555098 Free article.

5

Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice.

van Breda SG, van Agen E, van Sanden S, Burzykowski T, Kienhuis AS, Kleinjans JC, van Delft JH. van Breda SG, et al. Among authors: kienhuis as. J Nutr. 2005 Aug;135(8):1879-88. doi: 10.1093/jn/135.8.1879. J Nutr. 2005. PMID: 16046712 Free article.

6

Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals.

Stierum R, Heijne W, Kienhuis A, van Ommen B, Groten J. Stierum R, et al. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):179-88. doi: 10.1016/j.taap.2005.01.050. Toxicol Appl Pharmacol. 2005. PMID: 16139318 Review.

7

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology.

Heijne WH, Kienhuis AS, van Ommen B, Stierum RH, Groten JP. Heijne WH, et al. Among authors: kienhuis as. Expert Rev Proteomics. 2005 Oct;2(5):767-80. doi: 10.1586/14789450.2.5.767. Expert Rev Proteomics. 2005. PMID: 16209655 Review.

8

Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.

Kienhuis AS, Wortelboer HM, Hoflack JC, Moonen EJ, Kleinjans JC, van Ommen B, van Delft JH, Stierum RH. Kienhuis AS, et al. Drug Metab Dispos. 2006 Dec;34(12):2083-90. doi: 10.1124/dmd.106.011262. Epub 2006 Sep 8. Drug Metab Dispos. 2006. PMID: 16963487

9

A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.

Kienhuis AS, Wortelboer HM, Maas WJ, van Herwijnen M, Kleinjans JC, van Delft JH, Stierum RH. Kienhuis AS, et al. Toxicol In Vitro. 2007 Aug;21(5):892-901. doi: 10.1016/j.tiv.2007.01.010. Epub 2007 Jan 20. Toxicol In Vitro. 2007. PMID: 17336492

10

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Toxicol Sci. 2009 Feb;107(2):544-52. doi: 10.1093/toxsci/kfn237. Epub 2008 Nov 12. Toxicol Sci. 2009. PMID: 19008212

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