Kleinjans JC - Search Results

1

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Among authors: kleinjans jc. Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13. Toxicol In Vitro. 2009. PMID: 19527782

2

Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.

Kienhuis AS, Wortelboer HM, Hoflack JC, Moonen EJ, Kleinjans JC, van Ommen B, van Delft JH, Stierum RH. Kienhuis AS, et al. Among authors: kleinjans jc. Drug Metab Dispos. 2006 Dec;34(12):2083-90. doi: 10.1124/dmd.106.011262. Epub 2006 Sep 8. Drug Metab Dispos. 2006. PMID: 16963487

3

Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.

Kienhuis AS, van de Poll MC, Wortelboer H, van Herwijnen M, Gottschalk R, Dejong CH, Boorsma A, Paules RS, Kleinjans JC, Stierum RH, van Delft JH. Kienhuis AS, et al. Among authors: kleinjans jc. Toxicol Sci. 2009 Feb;107(2):544-52. doi: 10.1093/toxsci/kfn237. Epub 2008 Nov 12. Toxicol Sci. 2009. PMID: 19008212

4

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.

Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH. Mathijs K, et al. Among authors: kleinjans jc. Drug Metab Dispos. 2009 Jun;37(6):1305-11. doi: 10.1124/dmd.108.025775. Epub 2009 Feb 27. Drug Metab Dispos. 2009. PMID: 19251822

5

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time.

Mathijs K, Brauers KJ, Jennen DG, Boorsma A, van Herwijnen MH, Gottschalk RW, Kleinjans JC, van Delft JH. Mathijs K, et al. Among authors: kleinjans jc. Toxicol Sci. 2009 Dec;112(2):374-84. doi: 10.1093/toxsci/kfp229. Epub 2009 Sep 21. Toxicol Sci. 2009. PMID: 19770486

6

Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity.

Van Summeren A, Renes J, van Delft JH, Kleinjans JC, Mariman EC. Van Summeren A, et al. Among authors: kleinjans jc. Toxicol In Vitro. 2012 Apr;26(3):373-85. doi: 10.1016/j.tiv.2012.01.012. Epub 2012 Jan 17. Toxicol In Vitro. 2012. PMID: 22274661 Review.

7

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro.

Van den Hof WF, Ruiz-Aracama A, Van Summeren A, Jennen DG, Gaj S, Coonen ML, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC. Van den Hof WF, et al. Among authors: kleinjans jc. Toxicol In Vitro. 2015 Apr;29(3):489-501. doi: 10.1016/j.tiv.2014.12.016. Epub 2015 Jan 3. Toxicol In Vitro. 2015. PMID: 25562108

8

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

Jetten MJ, Ruiz-Aracama A, Coonen ML, Claessen SM, van Herwijnen MH, Lommen A, van Delft JH, Peijnenburg AA, Kleinjans JC. Jetten MJ, et al. Among authors: kleinjans jc. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24. Arch Toxicol. 2016. PMID: 26104854 Free PMC article.

9

A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.

Kienhuis AS, Wortelboer HM, Maas WJ, van Herwijnen M, Kleinjans JC, van Delft JH, Stierum RH. Kienhuis AS, et al. Among authors: kleinjans jc. Toxicol In Vitro. 2007 Aug;21(5):892-901. doi: 10.1016/j.tiv.2007.01.010. Epub 2007 Jan 20. Toxicol In Vitro. 2007. PMID: 17336492

10

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes.

Jetten MJ, Kleinjans JC, Claessen SM, Chesné C, van Delft JH. Jetten MJ, et al. Among authors: kleinjans jc. Toxicol In Vitro. 2013 Oct;27(7):2031-40. doi: 10.1016/j.tiv.2013.07.010. Epub 2013 Jul 31. Toxicol In Vitro. 2013. PMID: 23911569

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