Edwards CC - Search Results

1

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.

Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: edwards cc. J Med Chem. 2009 Jun 25;52(12):3742-52. doi: 10.1021/jm9001296. J Med Chem. 2009. PMID: 19534556 Free PMC article.

2

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. Among authors: edwards cc. J Med Chem. 2005 Apr 21;48(8):2906-15. doi: 10.1021/jm049011j. J Med Chem. 2005. PMID: 15828829

3

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM. Hyatt JL, et al. Among authors: edwards cc. J Med Chem. 2005 Aug 25;48(17):5543-50. doi: 10.1021/jm0504196. J Med Chem. 2005. PMID: 16107154

4

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM. Hyatt JL, et al. Among authors: edwards cc. Mol Cancer Ther. 2006 Sep;5(9):2281-8. doi: 10.1158/1535-7163.MCT-06-0160. Mol Cancer Ther. 2006. PMID: 16985062

5

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: edwards cc. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546

6

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: edwards cc. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. doi: 10.1016/j.bmc.2007.03.012. Epub 2007 Mar 12. Bioorg Med Chem. 2007. PMID: 17399985 Free PMC article.

7

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. Hyatt JL, et al. Among authors: edwards cc. J Med Chem. 2007 Nov 15;50(23):5727-34. doi: 10.1021/jm0706867. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941623

8

Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.

Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH. Barthel BL, et al. Among authors: edwards cc. J Med Chem. 2008 Jan 24;51(2):298-304. doi: 10.1021/jm7011479. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173233

9

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11.

Hatfield MJ, Tsurkan L, Garrett M, Shaver TM, Hyatt JL, Edwards CC, Hicks LD, Potter PM. Hatfield MJ, et al. Among authors: edwards cc. Biochem Pharmacol. 2011 Jan 1;81(1):24-31. doi: 10.1016/j.bcp.2010.09.001. Epub 2010 Sep 15. Biochem Pharmacol. 2011. PMID: 20833148 Free PMC article.

10

Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.

Parkinson EI, Jason Hatfield M, Tsurkan L, Hyatt JL, Edwards CC, Hicks LD, Yan B, Potter PM. Parkinson EI, et al. Among authors: edwards cc. Bioorg Med Chem. 2011 Aug 1;19(15):4635-43. doi: 10.1016/j.bmc.2011.06.012. Epub 2011 Jul 4. Bioorg Med Chem. 2011. PMID: 21733699 Free PMC article.

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