Tsurkan L - Search Results

1

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.

Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: tsurkan l. J Med Chem. 2009 Jun 25;52(12):3742-52. doi: 10.1021/jm9001296. J Med Chem. 2009. PMID: 19534556 Free PMC article.

2

Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.

Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR. Fleming CD, et al. Among authors: tsurkan l. J Mol Biol. 2005 Sep 9;352(1):165-77. doi: 10.1016/j.jmb.2005.07.016. J Mol Biol. 2005. PMID: 16081098

3

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: tsurkan l. Chem Biol Interact. 2005 Dec 15;157-158:247-52. doi: 10.1016/j.cbi.2005.10.033. Epub 2005 Oct 28. Chem Biol Interact. 2005. PMID: 16257398

4

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM. Hyatt JL, et al. Among authors: tsurkan l. Mol Cancer Ther. 2006 Sep;5(9):2281-8. doi: 10.1158/1535-7163.MCT-06-0160. Mol Cancer Ther. 2006. PMID: 16985062

5

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.

Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. Wadkins RM, et al. Among authors: tsurkan l. Mol Pharmacol. 2007 Mar;71(3):713-23. doi: 10.1124/mol.105.021683. Epub 2006 Dec 13. Mol Pharmacol. 2007. PMID: 17167034

6

Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.

Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS. Danks MK, et al. Among authors: tsurkan l. Cancer Res. 2007 Jan 1;67(1):22-5. doi: 10.1158/0008-5472.CAN-06-3607. Cancer Res. 2007. PMID: 17210679

7

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: tsurkan l. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546

8

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: tsurkan l. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. doi: 10.1016/j.bmc.2007.03.012. Epub 2007 Mar 12. Bioorg Med Chem. 2007. PMID: 17399985 Free PMC article.

9

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. Hyatt JL, et al. Among authors: tsurkan l. J Med Chem. 2007 Nov 15;50(23):5727-34. doi: 10.1021/jm0706867. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941623

10

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM. Wierdl M, et al. Among authors: tsurkan l. Cancer Gene Ther. 2008 Mar;15(3):183-92. doi: 10.1038/sj.cgt.7701112. Epub 2008 Jan 11. Cancer Gene Ther. 2008. PMID: 18188187

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