Reed JC - Search Results

1

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Kitada S, Rega MF, Stebbins JL, Zhai D, Cellitti J, Yuan H, Emdadi A, Dahl R, Zhang Z, Yang L, Reed JC, Pellecchia M. Wei J, et al. Among authors: reed jc. J Med Chem. 2009 Jul 23;52(14):4511-23. doi: 10.1021/jm900472s. J Med Chem. 2009. PMID: 19555126 Free PMC article.

2

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.

Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M. Kitada S, et al. Among authors: reed jc. J Med Chem. 2003 Sep 25;46(20):4259-64. doi: 10.1021/jm030190z. J Med Chem. 2003. PMID: 13678404

3

Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.

Leone M, Zhai D, Sareth S, Kitada S, Reed JC, Pellecchia M. Leone M, et al. Among authors: reed jc. Cancer Res. 2003 Dec 1;63(23):8118-21. Cancer Res. 2003. PMID: 14678963

4

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

Becattini B, Kitada S, Leone M, Monosov E, Chandler S, Zhai D, Kipps TJ, Reed JC, Pellecchia M. Becattini B, et al. Among authors: reed jc. Chem Biol. 2004 Mar;11(3):389-95. doi: 10.1016/j.chembiol.2004.02.020. Chem Biol. 2004. PMID: 15123268

5

Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy.

Pellecchia M, Reed JC. Pellecchia M, et al. Among authors: reed jc. Curr Pharm Des. 2004;10(12):1387-98. doi: 10.2174/1381612043384880. Curr Pharm Des. 2004. PMID: 15134489 Review.

6

Robust lanthanide-based assays for the detection of anti-apoptotic Bcl-2-family protein antagonists.

Rega MF, Reed JC, Pellecchia M. Rega MF, et al. Among authors: reed jc. Bioorg Chem. 2007 Apr;35(2):113-20. doi: 10.1016/j.bioorg.2006.07.006. Epub 2006 Sep 22. Bioorg Chem. 2007. PMID: 16996562

7

Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1.

Zhai D, Jin C, Huang Z, Satterthwait AC, Reed JC. Zhai D, et al. Among authors: reed jc. J Biol Chem. 2008 Apr 11;283(15):9580-6. doi: 10.1074/jbc.M708426200. Epub 2008 Jan 4. J Biol Chem. 2008. PMID: 18178565 Free PMC article.

8

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

Kitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC. Kitada S, et al. Among authors: reed jc. Blood. 2008 Mar 15;111(6):3211-9. doi: 10.1182/blood-2007-09-113647. Epub 2008 Jan 17. Blood. 2008. PMID: 18202226 Free PMC article.

9

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

Zhai D, Jin C, Shiau CW, Kitada S, Satterthwait AC, Reed JC. Zhai D, et al. Among authors: reed jc. Mol Cancer Ther. 2008 Jun;7(6):1639-46. doi: 10.1158/1535-7163.MCT-07-2373. Mol Cancer Ther. 2008. PMID: 18566235 Free PMC article.

10

Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists.

Wei J, Rega MF, Kitada S, Yuan H, Zhai D, Risbood P, Seltzman HH, Twine CE, Reed JC, Pellecchia M. Wei J, et al. Among authors: reed jc. Cancer Lett. 2009 Jan 8;273(1):107-13. doi: 10.1016/j.canlet.2008.07.031. Epub 2008 Sep 7. Cancer Lett. 2009. PMID: 18782651 Free PMC article.

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