Blankley CJ - Search Results

1

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.

Blankley CJ, Hodges JC, Klutchko SR, Himmelsbach RJ, Chucholowski A, Connolly CJ, Neergaard SJ, Van Nieuwenhze MS, Sebastian A, Quin J 3rd, et al. Blankley CJ, et al. J Med Chem. 1991 Nov;34(11):3248-60. doi: 10.1021/jm00115a014. J Med Chem. 1991. PMID: 1956044

2

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus.

Roth BD, Blankley CJ, Chucholowski AW, Ferguson E, Hoefle ML, Ortwine DF, Newton RS, Sekerke CS, Sliskovic DR, Stratton CD, et al. Roth BD, et al. Among authors: blankley cj. J Med Chem. 1991 Jan;34(1):357-66. doi: 10.1021/jm00105a056. J Med Chem. 1991. PMID: 1992137

3

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.

Roth BD, Bocan TM, Blankley CJ, Chucholowski AW, Creger PL, Creswell MW, Ferguson E, Newton RS, O'Brien P, Picard JA, et al. Roth BD, et al. Among authors: blankley cj. J Med Chem. 1991 Jan;34(1):463-6. doi: 10.1021/jm00105a071. J Med Chem. 1991. PMID: 1992149 No abstract available.

4

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.

Klutchko S, Blankley CJ, Fleming RW, Hinkley JM, Werner AE, Nordin I, Holmes A, Hoefle ML, Cohen DM, Essenburg AD, et al. Klutchko S, et al. Among authors: blankley cj. J Med Chem. 1986 Oct;29(10):1953-61. doi: 10.1021/jm00160a026. J Med Chem. 1986. PMID: 3020249

5

Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents.

White AD, Creswell MW, Chucholowski AW, Blankley CJ, Wilson MW, Bousley RF, Essenburg AD, Hamelehle KL, Krause BR, Stanfield RL, Dominick MA, Neub M. White AD, et al. Among authors: blankley cj. J Med Chem. 1996 Oct 25;39(22):4382-95. doi: 10.1021/jm960404v. J Med Chem. 1996. PMID: 8893833

6

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents.

Roth BD, Blankley CJ, Hoefle ML, Holmes A, Roark WH, Trivedi BK, Essenburg AD, Kieft KA, Krause BR, Stanfield RL. Roth BD, et al. Among authors: blankley cj. J Med Chem. 1992 May 1;35(9):1609-17. doi: 10.1021/jm00087a016. J Med Chem. 1992. PMID: 1578488

7

Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel beta-ketoamides as hypocholesterolemic agents.

Augelli-Szafran CE, Blankley CJ, Roth BD, Trivedi BK, Bousley RF, Essenburg AD, Hamelehle KL, Krause BR, Stanfield RL. Augelli-Szafran CE, et al. Among authors: blankley cj. J Med Chem. 1993 Oct 1;36(20):2943-9. doi: 10.1021/jm00072a014. J Med Chem. 1993. PMID: 8411011

8

N6-substituted adenosine receptor agonists: potential antihypertensive agents.

Trivedi BK, Blankley CJ, Bristol JA, Hamilton HW, Patt WC, Kramer WJ, Johnson SA, Bruns RF, Cohen DM, Ryan MJ. Trivedi BK, et al. Among authors: blankley cj. J Med Chem. 1991 Mar;34(3):1043-9. doi: 10.1021/jm00107a025. J Med Chem. 1991. PMID: 2002448

9

Evaluation of physicochemical parameters important to the oral bioavailability of peptide-like compounds: implications for the synthesis of renin inhibitors.

Hamilton HW, Steinbaugh BA, Stewart BH, Chan OH, Schmid HL, Schroeder R, Ryan MJ, Keiser J, Taylor MD, Blankley CJ, et al. Hamilton HW, et al. Among authors: blankley cj. J Med Chem. 1995 Apr 28;38(9):1446-55. doi: 10.1021/jm00009a005. J Med Chem. 1995. PMID: 7739003

10

Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents.

Trivedi BK, Holmes A, Stoeber TL, Blankley CJ, Roark WH, Picard JA, Shaw MK, Essenburg AD, Stanfield RL, Krause BR. Trivedi BK, et al. Among authors: blankley cj. J Med Chem. 1993 Oct 29;36(22):3300-7. doi: 10.1021/jm00074a011. J Med Chem. 1993. PMID: 8230120

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