Klutchko SR - Search Results

1

Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.

Blankley CJ, Hodges JC, Klutchko SR, Himmelsbach RJ, Chucholowski A, Connolly CJ, Neergaard SJ, Van Nieuwenhze MS, Sebastian A, Quin J 3rd, et al. Blankley CJ, et al. Among authors: klutchko sr. J Med Chem. 1991 Nov;34(11):3248-60. doi: 10.1021/jm00115a014. J Med Chem. 1991. PMID: 1956044

2

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

Edmunds JJ, Klutchko S, Hamby JM, Bunker AM, Connolly CJ, Winters RT, Quin J 3rd, Sircar I, Hodges JC, Panek RL, et al. Edmunds JJ, et al. J Med Chem. 1995 Sep 15;38(19):3759-71. doi: 10.1021/jm00019a005. J Med Chem. 1995. PMID: 7562906

3

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

Patt WC, Hamilton HW, Taylor MD, Ryan MJ, Taylor DG Jr, Connolly CJ, Doherty AM, Klutchko SR, Sircar I, Steinbaugh BA, et al. Patt WC, et al. Among authors: klutchko sr. J Med Chem. 1992 Jul 10;35(14):2562-72. doi: 10.1021/jm00092a006. J Med Chem. 1992. PMID: 1635057

4

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.

Klutchko S, Blankley CJ, Fleming RW, Hinkley JM, Werner AE, Nordin I, Holmes A, Hoefle ML, Cohen DM, Essenburg AD, et al. Klutchko S, et al. J Med Chem. 1986 Oct;29(10):1953-61. doi: 10.1021/jm00160a026. J Med Chem. 1986. PMID: 3020249

5

2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.

Klutchko SR, Hamby JM, Boschelli DH, Wu Z, Kraker AJ, Amar AM, Hartl BG, Shen C, Klohs WD, Steinkampf RW, Driscoll DL, Nelson JM, Elliott WL, Roberts BJ, Stoner CL, Vincent PW, Dykes DJ, Panek RL, Lu GH, Major TC, Dahring TK, Hallak H, Bradford LA, Showalter HD, Doherty AM. Klutchko SR, et al. J Med Chem. 1998 Aug 13;41(17):3276-92. doi: 10.1021/jm9802259. J Med Chem. 1998. PMID: 9703473

6

Synthesis and tyrosine kinase inhibitory activity of a series of 2-amino-8H-pyrido[2,3-d]pyrimidines: identification of potent, selective platelet-derived growth factor receptor tyrosine kinase inhibitors.

Boschelli DH, Wu Z, Klutchko SR, Showalter HD, Hamby JM, Lu GH, Major TC, Dahring TK, Batley B, Panek RL, Keiser J, Hartl BG, Kraker AJ, Klohs WD, Roberts BJ, Patmore S, Elliott WL, Steinkampf R, Bradford LA, Hallak H, Doherty AM. Boschelli DH, et al. Among authors: klutchko sr. J Med Chem. 1998 Oct 22;41(22):4365-77. doi: 10.1021/jm980398y. J Med Chem. 1998. PMID: 9784112

7

Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.

Klutchko SR, Zhou H, Winters RT, Tran TP, Bridges AJ, Althaus IW, Amato DM, Elliott WL, Ellis PA, Meade MA, Roberts BJ, Fry DW, Gonzales AJ, Harvey PJ, Nelson JM, Sherwood V, Han HK, Pace G, Smaill JB, Denny WA, Showalter HD. Klutchko SR, et al. J Med Chem. 2006 Feb 23;49(4):1475-85. doi: 10.1021/jm050936o. J Med Chem. 2006. PMID: 16480284

8

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.

Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. Rao CM, et al. J Med Chem. 1993 Sep 3;36(18):2614-20. doi: 10.1021/jm00070a004. J Med Chem. 1993. PMID: 8410973

9

In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor.

Panek RL, Lu GH, Klutchko SR, Batley BL, Dahring TK, Hamby JM, Hallak H, Doherty AM, Keiser JA. Panek RL, et al. Among authors: klutchko sr. J Pharmacol Exp Ther. 1997 Dec;283(3):1433-44. J Pharmacol Exp Ther. 1997. PMID: 9400019

10

Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(Mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acids.

Klutchko S, Hoefle ML, Smith RD, Essenburg AD, Parker RB, Nemeth VL, Ryan MJ, Dugan DH, Kaplan HR. Klutchko S, et al. J Med Chem. 1981 Jan;24(1):104-9. doi: 10.1021/jm00133a021. J Med Chem. 1981. PMID: 6259352

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