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Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice.
Zou X, Osborn MJ, Bolland DJ, Smith JA, Corcos D, Hamon M, Oxley D, Hutchings A, Morgan G, Santos F, Kilshaw PJ, Taussig MJ, Corcoran AE, Brüggemann M. Zou X, et al. Among authors: bruggemann m. J Exp Med. 2007 Dec 24;204(13):3271-83. doi: 10.1084/jem.20071155. Epub 2007 Dec 17. J Exp Med. 2007. PMID: 18086860 Free PMC article.
High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.
Osborn MJ, Ma B, Avis S, Binnie A, Dilley J, Yang X, Lindquist K, Ménoret S, Iscache AL, Ouisse LH, Rajpal A, Anegon I, Neuberger MS, Buelow R, Brüggemann M. Osborn MJ, et al. Among authors: bruggemann m. J Immunol. 2013 Feb 15;190(4):1481-90. doi: 10.4049/jimmunol.1203041. Epub 2013 Jan 9. J Immunol. 2013. PMID: 23303672 Free PMC article.
294 results