Middleton MR - Search Results

1

Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells.

Sabharwal A, Waters R, Danson S, Clamp A, Lorigan P, Thatcher N, Margison GP, Middleton MR. Sabharwal A, et al. Among authors: middleton mr. Melanoma Res. 2011 Dec;21(6):502-8. doi: 10.1097/CMR.0b013e32832ccd58. Melanoma Res. 2011. PMID: 19561552

2

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

Middleton MR, Lunn JM, Morris C, Rustin G, Wedge SR, Brampton MH, Lind MJ, Lee SM, Newell DR, Bleehen NM, Newlands ES, Calvert AH, Margison GP, Thatcher N. Middleton MR, et al. Br J Cancer. 1998 Nov;78(9):1199-202. doi: 10.1038/bjc.1998.654. Br J Cancer. 1998. PMID: 9820180 Free PMC article. Clinical Trial.

3

Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.

McElhinney RS, Donnelly DJ, McCormick JE, Kelly J, Watson AJ, Rafferty JA, Elder RH, Middleton MR, Willington MA, McMurry TB, Margison GP. McElhinney RS, et al. Among authors: middleton mr. J Med Chem. 1998 Dec 17;41(26):5265-71. doi: 10.1021/jm9708644. J Med Chem. 1998. PMID: 9857094

4

Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma.

Middleton MR, Grob JJ, Aaronson N, Fierlbeck G, Tilgen W, Seiter S, Gore M, Aamdal S, Cebon J, Coates A, Dreno B, Henz M, Schadendorf D, Kapp A, Weiss J, Fraass U, Statkevich P, Muller M, Thatcher N. Middleton MR, et al. J Clin Oncol. 2000 Jan;18(1):158-66. doi: 10.1200/JCO.2000.18.1.158. J Clin Oncol. 2000. PMID: 10623706 Clinical Trial.

5

O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.

Middleton MR, Kelly J, Thatcher N, Donnelly DJ, McElhinney RS, McMurry TB, McCormick JE, Margison GP. Middleton MR, et al. Int J Cancer. 2000 Jan 15;85(2):248-52. doi: 10.1002/(sici)1097-0215(20000115)85:2<248::aid-ijc16>3.0.co;2-v. Int J Cancer. 2000. PMID: 10629085

6

Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.

Middleton MR, Kelly J, Goodger S, Thatcher N, Margison GP. Middleton MR, et al. Cancer Chemother Pharmacol. 2000;45(1):15-20. doi: 10.1007/PL00006737. Cancer Chemother Pharmacol. 2000. PMID: 10647496

7

A randomized phase III study comparing dacarbazine, BCNU, cisplatin and tamoxifen with dacarbazine and interferon in advanced melanoma.

Middleton MR, Lorigan P, Owen J, Ashcroft L, Lee SM, Harper P, Thatcher N. Middleton MR, et al. Br J Cancer. 2000 Mar;82(6):1158-62. doi: 10.1054/bjoc.1999.1056. Br J Cancer. 2000. PMID: 10735499 Free PMC article. Clinical Trial.

8

O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study.

Middleton MR, Lee SM, Arance A, Wood M, Thatcher N, Margison GP. Middleton MR, et al. Int J Cancer. 2000 Nov 1;88(3):469-73. Int J Cancer. 2000. PMID: 11054678 Clinical Trial.

9

Adjuvant interferon in melanoma - a resurrection?

Middleton MR, Thatcher N. Middleton MR, et al. Br J Cancer. 2001 May 4;84(9):1141-2. doi: 10.1054/bjoc.2001.1798. Br J Cancer. 2001. PMID: 11336461 Free PMC article. No abstract available.

10

Randomized phase II study of cyclophosphamide, doxorubicin, and vincristine compared with single-agent carboplatin in patients with poor prognosis small cell lung carcinoma.

White SC, Lorigan P, Middleton MR, Anderson H, Valle J, Summers Y, Burt PA, Arance A, Stout R, Thatcher N. White SC, et al. Among authors: middleton mr. Cancer. 2001 Aug 1;92(3):601-8. doi: 10.1002/1097-0142(20010801)92:3<601::aid-cncr1360>3.0.co;2-k. Cancer. 2001. PMID: 11505405 Clinical Trial.

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