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PI3K: A master regulator of brain metastasis-promoting macrophages/microglia.
Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T. Blazquez R, et al. Among authors: siam l. Glia. 2018 Nov;66(11):2438-2455. doi: 10.1002/glia.23485. Epub 2018 Oct 25. Glia. 2018. PMID: 30357946
LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.
Blazquez R, Rietkötter E, Wenske B, Wlochowitz D, Sparrer D, Vollmer E, Müller G, Seegerer J, Sun X, Dettmer K, Barrantes-Freer A, Stange L, Utpatel K, Bleckmann A, Treiber H, Bohnenberger H, Lenz C, Schulz M, Reimelt C, Hackl C, Grade M, Büyüktas D, Siam L, Balkenhol M, Stadelmann C, Kube D, Krahn MP, Proescholdt MA, Riemenschneider MJ, Evert M, Oefner PJ, Klein CA, Hanisch UK, Binder C, Pukrop T. Blazquez R, et al. Among authors: siam l. Int J Cancer. 2020 Jun 1;146(11):3170-3183. doi: 10.1002/ijc.32742. Epub 2019 Nov 11. Int J Cancer. 2020. PMID: 31626715
Carcinoma cells misuse the host tissue damage response to invade the brain.
Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T. Chuang HN, et al. Among authors: siam l. Glia. 2013 Aug;61(8):1331-46. doi: 10.1002/glia.22518. Epub 2013 Jul 6. Glia. 2013. PMID: 23832647 Free PMC article.
β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis.
Klemm F, Bleckmann A, Siam L, Chuang HN, Rietkötter E, Behme D, Schulz M, Schaffrinski M, Schindler S, Trümper L, Kramer F, Beissbarth T, Stadelmann C, Binder C, Pukrop T. Klemm F, et al. Among authors: siam l. Carcinogenesis. 2011 Mar;32(3):434-42. doi: 10.1093/carcin/bgq269. Epub 2010 Dec 20. Carcinogenesis. 2011. PMID: 21173432
20 results