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Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-n-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na+-Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in stably transfected cells.
Secondo A, Pannaccione A, Molinaro P, Ambrosino P, Lippiello P, Esposito A, Cantile M, Khatri PR, Melisi D, Di Renzo G, Annunziato L. Secondo A, et al. Among authors: ambrosino p. J Pharmacol Exp Ther. 2009 Oct;331(1):212-21. doi: 10.1124/jpet.109.152132. Epub 2009 Jul 14. J Pharmacol Exp Ther. 2009. PMID: 19602550
Neurounina-1, a novel compound that increases Na+/Ca2+ exchanger activity, effectively protects against stroke damage.
Molinaro P, Cantile M, Cuomo O, Secondo A, Pannaccione A, Ambrosino P, Pignataro G, Fiorino F, Severino B, Gatta E, Sisalli MJ, Milanese M, Scorziello A, Bonanno G, Robello M, Santagada V, Caliendo G, Di Renzo G, Annunziato L. Molinaro P, et al. Among authors: ambrosino p. Mol Pharmacol. 2013 Jan;83(1):142-56. doi: 10.1124/mol.112.080986. Epub 2012 Oct 11. Mol Pharmacol. 2013. PMID: 23066092
Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons.
Mancini M, Soldovieri MV, Gessner G, Wissuwa B, Barrese V, Boscia F, Secondo A, Miceli F, Franco C, Ambrosino P, Canzoniero LM, Bauer M, Hoshi T, Heinemann SH, Taglialatela M. Mancini M, et al. Among authors: ambrosino p. Pharmacol Res. 2014 Sep;87:80-6. doi: 10.1016/j.phrs.2014.06.010. Epub 2014 Jun 26. Pharmacol Res. 2014. PMID: 24973659 Free PMC article.
Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.
Secondo A, Pignataro G, Ambrosino P, Pannaccione A, Molinaro P, Boscia F, Cantile M, Cuomo O, Esposito A, Sisalli MJ, Scorziello A, Guida N, Anzilotti S, Fiorino F, Severino B, Santagada V, Caliendo G, Di Renzo G, Annunziato L. Secondo A, et al. Among authors: ambrosino p. ACS Chem Neurosci. 2015 Aug 19;6(8):1361-70. doi: 10.1021/acschemneuro.5b00043. Epub 2015 May 19. ACS Chem Neurosci. 2015. PMID: 25942323
Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators.
Bertamino A, Ostacolo C, Ambrosino P, Musella S, Di Sarno V, Ciaglia T, Soldovieri MV, Iraci N, Fernandez Carvajal A, de la Torre-Martinez R, Ferrer-Montiel A, Gonzalez Muniz R, Novellino E, Taglialatela M, Campiglia P, Gomez-Monterrey I. Bertamino A, et al. Among authors: ambrosino p. J Med Chem. 2016 Mar 10;59(5):2179-91. doi: 10.1021/acs.jmedchem.5b01914. Epub 2016 Feb 17. J Med Chem. 2016. PMID: 26847872 Free article.
206 results