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A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.
Twine S, Byström M, Chen W, Forsman M, Golovliov I, Johansson A, Kelly J, Lindgren H, Svensson K, Zingmark C, Conlan W, Sjöstedt A. Twine S, et al. Among authors: conlan w. Infect Immun. 2005 Dec;73(12):8345-52. doi: 10.1128/IAI.73.12.8345-8352.2005. Infect Immun. 2005. PMID: 16299332 Free PMC article.
An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy.
Golovliov I, Lindgren H, Eneslätt K, Conlan W, Mosnier A, Henry T, Sjöstedt A. Golovliov I, et al. Among authors: conlan w. Front Cell Infect Microbiol. 2016 Nov 25;6:152. doi: 10.3389/fcimb.2016.00152. eCollection 2016. Front Cell Infect Microbiol. 2016. PMID: 27933275 Free PMC article.
Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria.
Ryden P, Twine S, Shen H, Harris G, Chen W, Sjostedt A, Conlan W. Ryden P, et al. Among authors: conlan w. Mol Immunol. 2013 May;54(1):58-67. doi: 10.1016/j.molimm.2012.10.043. Epub 2012 Nov 28. Mol Immunol. 2013. PMID: 23201853
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