Brien GL - Search Results

1

Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation.

Brien GL, Bracken AP. Brien GL, et al. Semin Cell Dev Biol. 2009 Sep;20(7):835-41. doi: 10.1016/j.semcdb.2009.07.010. Epub 2009 Aug 12. Semin Cell Dev Biol. 2009. PMID: 19682593 Review.

2

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.

Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. Brien GL, et al. Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18. Nat Struct Mol Biol. 2012. PMID: 23160351

3

Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.

Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP. Lanigan F, et al. Among authors: brien gl. FEBS J. 2015 Sep;282(18):3455-73. doi: 10.1111/febs.13354. Epub 2015 Jul 14. FEBS J. 2015. PMID: 26094870 Free article.

4

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.

Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP. Brien GL, et al. Genes Dev. 2015 Nov 1;29(21):2231-43. doi: 10.1101/gad.267930.115. Epub 2015 Oct 22. Genes Dev. 2015. PMID: 26494712 Free PMC article.

5

The PCL1-p53 axis promotes cellular quiescence.

Brien GL, Bracken AP. Brien GL, et al. Cell Cycle. 2016;15(3):305-6. doi: 10.1080/15384101.2015.1124701. Epub 2015 Dec 10. Cell Cycle. 2016. PMID: 26652297 Free PMC article. No abstract available.

6

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

Oliviero G, Brien GL, Waston A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Wynne K, Crean J, Bracken AP, Cagney G. Oliviero G, et al. Among authors: brien gl. Mol Cell Proteomics. 2016 Nov;15(11):3450-3460. doi: 10.1074/mcp.M116.062240. Epub 2016 Sep 15. Mol Cell Proteomics. 2016. PMID: 27634302 Free PMC article.

7

The 3D Genome: EZH2 Comes into the Fold.

Brien GL, Bracken AP. Brien GL, et al. Trends Mol Med. 2019 May;25(5):362-365. doi: 10.1016/j.molmed.2019.02.013. Epub 2019 Mar 15. Trends Mol Med. 2019. PMID: 30885427

8

Targeting chromatin complexes in fusion protein-driven malignancies.

Brien GL, Stegmaier K, Armstrong SA. Brien GL, et al. Nat Rev Cancer. 2019 May;19(5):255-269. doi: 10.1038/s41568-019-0132-x. Nat Rev Cancer. 2019. PMID: 30962549 Review.

9

Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer.

Bracken AP, Brien GL, Verrijzer CP. Bracken AP, et al. Among authors: brien gl. Genes Dev. 2019 Aug 1;33(15-16):936-959. doi: 10.1101/gad.326066.119. Epub 2019 May 23. Genes Dev. 2019. PMID: 31123059 Free PMC article. Review.

10

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.

Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP. Brien GL, et al. Nat Genet. 2021 Aug;53(8):1221-1232. doi: 10.1038/s41588-021-00897-w. Epub 2021 Jul 22. Nat Genet. 2021. PMID: 34294917

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