Saavedra A - Search Results

1

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

Xifró X, Giralt A, Saavedra A, García-Martínez JM, Díaz-Hernández M, Lucas JJ, Alberch J, Pérez-Navarro E. Xifró X, et al. Among authors: saavedra a. Neurobiol Dis. 2009 Dec;36(3):461-9. doi: 10.1016/j.nbd.2009.08.012. Epub 2009 Sep 4. Neurobiol Dis. 2009. PMID: 19733666

2

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

Saavedra A, García-Martínez JM, Xifró X, Giralt A, Torres-Peraza JF, Canals JM, Díaz-Hernández M, Lucas JJ, Alberch J, Pérez-Navarro E. Saavedra A, et al. Cell Death Differ. 2010 Feb;17(2):324-35. doi: 10.1038/cdd.2009.127. Epub 2009 Sep 11. Cell Death Differ. 2010. PMID: 19745829

3

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.

Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E. Saavedra A, et al. J Neurosci. 2011 Jun 1;31(22):8150-62. doi: 10.1523/JNEUROSCI.3446-10.2011. J Neurosci. 2011. PMID: 21632937 Free PMC article.

4

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.

Giralt A, Saavedra A, Carretón O, Xifró X, Alberch J, Pérez-Navarro E. Giralt A, et al. Among authors: saavedra a. Hum Mol Genet. 2011 Nov 1;20(21):4232-47. doi: 10.1093/hmg/ddr351. Epub 2011 Aug 11. Hum Mol Genet. 2011. PMID: 21835884

5

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Xifró X, Anglada-Huguet M, Rué L, Saavedra A, Pérez-Navarro E, Alberch J. Xifró X, et al. Among authors: saavedra a. Mol Neurodegener. 2011 Oct 31;6:74. doi: 10.1186/1750-1326-6-74. Mol Neurodegener. 2011. PMID: 22041125 Free PMC article.

6

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.

Giralt A, Saavedra A, Carretón O, Arumí H, Tyebji S, Alberch J, Pérez-Navarro E. Giralt A, et al. Among authors: saavedra a. Hippocampus. 2013 Aug;23(8):684-95. doi: 10.1002/hipo.22128. Epub 2013 Apr 29. Hippocampus. 2013. PMID: 23576401

7

Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease.

Saavedra A, Giralt A, Arumí H, Alberch J, Pérez-Navarro E. Saavedra A, et al. PLoS One. 2013 Sep 5;8(9):e73664. doi: 10.1371/journal.pone.0073664. eCollection 2013. PLoS One. 2013. PMID: 24040016 Free PMC article.

8

Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms.

Giralt A, Saavedra A, Alberch J, Pérez-Navarro E. Giralt A, et al. Among authors: saavedra a. J Huntingtons Dis. 2012;1(2):155-73. doi: 10.3233/JHD-120023. J Huntingtons Dis. 2012. PMID: 25063329 Free article. Review.

9

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Tyebji S, Saavedra A, Canas PM, Pliassova A, Delgado-García JM, Alberch J, Cunha RA, Gruart A, Pérez-Navarro E. Tyebji S, et al. Among authors: saavedra a. Neurobiol Dis. 2015 Feb;74:41-57. doi: 10.1016/j.nbd.2014.11.004. Epub 2014 Nov 11. Neurobiol Dis. 2015. PMID: 25449908

10

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.

Saavedra A, Puigdellívol M, Tyebji S, Kurup P, Xu J, Ginés S, Alberch J, Lombroso PJ, Pérez-Navarro E. Saavedra A, et al. Mol Neurobiol. 2016 Aug;53(6):4261-4273. doi: 10.1007/s12035-015-9335-7. Epub 2015 Jul 30. Mol Neurobiol. 2016. PMID: 26223799 Free PMC article.

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