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Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T, Heitzer T. Baldus S, et al. Among authors: klinke a. Circulation. 2006 Apr 18;113(15):1871-8. doi: 10.1161/CIRCULATIONAHA.105.590083. Epub 2006 Apr 10. Circulation. 2006. PMID: 16606792
Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase.
Rudolph V, Rudolph TK, Schopfer FJ, Bonacci G, Lau D, Szöcs K, Klinke A, Meinertz T, Freeman BA, Baldus S. Rudolph V, et al. Among authors: klinke a. J Pharmacol Exp Ther. 2008 Nov;327(2):324-31. doi: 10.1124/jpet.108.142414. Epub 2008 Aug 13. J Pharmacol Exp Ther. 2008. PMID: 18701766 Free PMC article. Clinical Trial.
Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S. Rudolph V, et al. Among authors: klinke a. Nat Med. 2010 Apr;16(4):470-4. doi: 10.1038/nm.2124. Epub 2010 Mar 21. Nat Med. 2010. PMID: 20305660 Free PMC article.
Myeloperoxidase attracts neutrophils by physical forces.
Klinke A, Nussbaum C, Kubala L, Friedrichs K, Rudolph TK, Rudolph V, Paust HJ, Schröder C, Benten D, Lau D, Szocs K, Furtmüller PG, Heeringa P, Sydow K, Duchstein HJ, Ehmke H, Schumacher U, Meinertz T, Sperandio M, Baldus S. Klinke A, et al. Blood. 2011 Jan 27;117(4):1350-8. doi: 10.1182/blood-2010-05-284513. Epub 2010 Oct 27. Blood. 2011. PMID: 20980678 Free article.
Myeloperoxidase deficiency preserves vasomotor function in humans.
Rudolph TK, Wipper S, Reiter B, Rudolph V, Coym A, Detter C, Lau D, Klinke A, Friedrichs K, Rau T, Pekarova M, Russ D, Knöll K, Kolk M, Schroeder B, Wegscheider K, Andresen H, Schwedhelm E, Boeger R, Ehmke H, Baldus S. Rudolph TK, et al. Among authors: klinke a. Eur Heart J. 2012 Jul;33(13):1625-34. doi: 10.1093/eurheartj/ehr193. Epub 2011 Jun 30. Eur Heart J. 2012. PMID: 21724624 Free PMC article.
Inflammatory pathways underlying atrial fibrillation.
Friedrichs K, Klinke A, Baldus S. Friedrichs K, et al. Among authors: klinke a. Trends Mol Med. 2011 Oct;17(10):556-63. doi: 10.1016/j.molmed.2011.05.007. Epub 2011 Jul 15. Trends Mol Med. 2011. PMID: 21763201 Review.
79 results