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Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells.
Yeang HXA, Hamdam JM, Al-Huseini LMA, Sethu S, Djouhri L, Walsh J, Kitteringham N, Park BK, Goldring CE, Sathish JG. Yeang HXA, et al. Among authors: sathish jg. J Biol Chem. 2012 Mar 23;287(13):10556-10564. doi: 10.1074/jbc.M111.322420. Epub 2012 Feb 6. J Biol Chem. 2012. PMID: 22311972 Free PMC article.
Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.
Al-Huseini LM, Aw Yeang HX, Sethu S, Alhumeed N, Hamdam JM, Tingle Y, Djouhri L, Kitteringham N, Park BK, Goldring CE, Sathish JG. Al-Huseini LM, et al. Among authors: sathish jg. J Biol Chem. 2013 Aug 2;288(31):22281-8. doi: 10.1074/jbc.M113.483420. Epub 2013 Jun 17. J Biol Chem. 2013. PMID: 23775080 Free PMC article.
Challenges and approaches for the development of safer immunomodulatory biologics.
Sathish JG, Sethu S, Bielsky MC, de Haan L, French NS, Govindappa K, Green J, Griffiths CE, Holgate S, Jones D, Kimber I, Moggs J, Naisbitt DJ, Pirmohamed M, Reichmann G, Sims J, Subramanyam M, Todd MD, Van Der Laan JW, Weaver RJ, Park BK. Sathish JG, et al. Nat Rev Drug Discov. 2013 Apr;12(4):306-24. doi: 10.1038/nrd3974. Nat Rev Drug Discov. 2013. PMID: 23535934 Free PMC article. Review.
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.
Thaventhiran T, Alhumeed N, Yeang HX, Sethu S, Downey JS, Alghanem AF, Olayanju A, Smith EL, Cross MJ, Webb SD, Williams DP, Bristow A, Ball C, Stebbings R, Sathish JG. Thaventhiran T, et al. Among authors: sathish jg. MAbs. 2014;6(5):1290-9. doi: 10.4161/mabs.29758. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517314 Free PMC article.
CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.
Thaventhiran T, Wong W, Alghanem AF, Alhumeed N, Aljasir MA, Ramsey S, Sethu S, Yeang HXA, Chadwick AE, Cross M, Webb SD, Djouhri L, Ball C, Stebbings R, Sathish JG. Thaventhiran T, et al. Among authors: sathish jg. Monoclon Antib Immunodiagn Immunother. 2019 Apr;38(2):60-69. doi: 10.1089/mab.2018.0042. Monoclon Antib Immunodiagn Immunother. 2019. PMID: 31009338 Free PMC article.
34 results