In vitro selection of RNase P RNA reveals optimized catalytic activity in a highly conserved structural domain.
Frank DN, Ellington AE, Pace NR.
Frank DN, et al.
RNA. 1996 Dec;2(12):1179-88.
RNA. 1996.
PMID: 8972768
Free PMC article.
Using a self-cleaving conjugate containing the Escherichia coli ribonuclease P RNA and its substrate, pre-tRNA (Frank DN, Harris ME, Pace NR, 1994, Biochemistry 33:10800-10808), we have devised a method to select for catalytically active variants of the RNase P ribo …
Using a self-cleaving conjugate containing the Escherichia coli ribonuclease P RNA and its substrate, pre-tRNA (Frank DN, Harr …