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761 results

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Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe.
Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW. Weaver CD, et al. Among authors: lindsley cw. Curr Top Med Chem. 2009;9(13):1217-26. doi: 10.2174/156802609789753635. Curr Top Med Chem. 2009. PMID: 19807667 Free PMC article. Review.
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL Jr, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR. Lindsley CW, et al. J Med Chem. 2004 Nov 18;47(24):5825-8. doi: 10.1021/jm049400d. J Med Chem. 2004. PMID: 15537338
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
Zhao Z, Wisnoski DD, O'Brien JA, Lemaire W, Williams DL Jr, Jacobson MA, Wittman M, Ha SN, Schaffhauser H, Sur C, Pettibone DJ, Duggan ME, Conn PJ, Hartman GD, Lindsley CW. Zhao Z, et al. Among authors: lindsley cw. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1386-91. doi: 10.1016/j.bmcl.2006.11.081. Epub 2006 Dec 3. Bioorg Med Chem Lett. 2007. PMID: 17210250
Emerging from the shadow of Vioxx.
Lindsley CW. Lindsley CW. Curr Top Med Chem. 2007;7(7):739. doi: 10.2174/156802607780487777. Curr Top Med Chem. 2007. PMID: 17450647 No abstract available.
A new, non-SSRI mechanism of action for Prozac.
Daniels RN, Lindsley CW. Daniels RN, et al. Among authors: lindsley cw. Curr Top Med Chem. 2007;7(10):1039. doi: 10.2174/156802607780906807. Curr Top Med Chem. 2007. PMID: 17563945 No abstract available.
761 results