Okazaki O - Search Results

1

Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.

Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A. Kazui M, et al. Among authors: okazaki o. Drug Metab Dispos. 2010 Jan;38(1):92-9. doi: 10.1124/dmd.109.029132. Drug Metab Dispos. 2010. PMID: 19812348

2

A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.

Hagihara K, Kazui M, Kurihara A, Yoshiike M, Honda K, Okazaki O, Farid NA, Ikeda T. Hagihara K, et al. Among authors: okazaki o. Drug Metab Dispos. 2009 Nov;37(11):2145-52. doi: 10.1124/dmd.109.028498. Epub 2009 Aug 24. Drug Metab Dispos. 2009. PMID: 19704027

3

Biotransformation of prasugrel, a novel thienopyridine antiplatelet agent, to the pharmacologically active metabolite.

Hagihara K, Kazui M, Kurihara A, Iwabuchi H, Ishikawa M, Kobayashi H, Tanaka N, Okazaki O, Farid NA, Ikeda T. Hagihara K, et al. Among authors: okazaki o. Drug Metab Dispos. 2010 Jun;38(6):898-904. doi: 10.1124/dmd.110.032086. Epub 2010 Mar 12. Drug Metab Dispos. 2010. PMID: 20228231

4

Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.

Hagihara K, Kazui M, Ikenaga H, Nanba T, Fusegawa K, Takahashi M, Kurihara A, Okazaki O, Farid NA, Ikeda T. Hagihara K, et al. Among authors: okazaki o. Xenobiotica. 2009 Mar;39(3):218-26. doi: 10.1080/00498250802650077. Xenobiotica. 2009. PMID: 19280520

5

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.

Nishiya Y, Hagihara K, Kurihara A, Okudaira N, Farid NA, Okazaki O, Ikeda T. Nishiya Y, et al. Among authors: okazaki o. Xenobiotica. 2009 Nov;39(11):836-43. doi: 10.3109/00498250903191427. Xenobiotica. 2009. PMID: 19845434

6

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.

Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O. Nakayama S, et al. Among authors: okazaki o. Drug Metab Dispos. 2009 Sep;37(9):1970-7. doi: 10.1124/dmd.109.027797. Epub 2009 Jun 1. Drug Metab Dispos. 2009. PMID: 19487250

7

Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine.

Ishizuka T, Fujimori I, Kato M, Noji-Sakikawa C, Saito M, Yoshigae Y, Kubota K, Kurihara A, Izumi T, Ikeda T, Okazaki O. Ishizuka T, et al. Among authors: okazaki o. J Biol Chem. 2010 Apr 16;285(16):11892-902. doi: 10.1074/jbc.M109.072629. Epub 2010 Feb 19. J Biol Chem. 2010. PMID: 20177059 Free PMC article.

8

Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide.

Sawamura R, Okudaira N, Watanabe K, Murai T, Kobayashi Y, Tachibana M, Ohnuki T, Masuda K, Honma H, Kurihara A, Okazaki O. Sawamura R, et al. Among authors: okazaki o. Drug Metab Dispos. 2010 Oct;38(10):1857-64. doi: 10.1124/dmd.110.034173. Epub 2010 Jul 6. Drug Metab Dispos. 2010. PMID: 20606003

9

Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach.

Deguchi T, Watanabe N, Kurihara A, Igeta K, Ikenaga H, Fusegawa K, Suzuki N, Murata S, Hirouchi M, Furuta Y, Iwasaki M, Okazaki O, Izumi T. Deguchi T, et al. Among authors: okazaki o. Drug Metab Dispos. 2011 May;39(5):820-9. doi: 10.1124/dmd.110.037457. Epub 2011 Jan 31. Drug Metab Dispos. 2011. PMID: 21282406

10

Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats.

Miyaji Y, Walter S, Chen L, Kurihara A, Ishizuka T, Saito M, Kawai K, Okazaki O. Miyaji Y, et al. Among authors: okazaki o. Drug Metab Dispos. 2011 Oct;39(10):1946-53. doi: 10.1124/dmd.111.040725. Epub 2011 Jun 28. Drug Metab Dispos. 2011. PMID: 21712433

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