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Page 1
Cloning and pharmacological characterization of the dog P2X7 receptor.
Roman S, Cusdin FS, Fonfria E, Goodwin JA, Reeves J, Lappin SC, Chambers L, Walter DS, Clay WC, Michel AD. Roman S, et al. Among authors: lappin sc. Br J Pharmacol. 2009 Nov;158(6):1513-26. doi: 10.1111/j.1476-5381.2009.00425.x. Epub 2009 Oct 8. Br J Pharmacol. 2009. PMID: 19814727 Free PMC article.
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Gunthorpe MJ, Hannan SL, Smart D, Jerman JC, Arpino S, Smith GD, Brough S, Wright J, Egerton J, Lappin SC, Holland VA, Winborn K, Thompson M, Rami HK, Randall A, Davis JB. Gunthorpe MJ, et al. Among authors: lappin sc. J Pharmacol Exp Ther. 2007 Jun;321(3):1183-92. doi: 10.1124/jpet.106.116657. Epub 2007 Mar 28. J Pharmacol Exp Ther. 2007. PMID: 17392405
Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.
Gunthorpe MJ, Rami HK, Jerman JC, Smart D, Gill CH, Soffin EM, Luis Hannan S, Lappin SC, Egerton J, Smith GD, Worby A, Howett L, Owen D, Nasir S, Davies CH, Thompson M, Wyman PA, Randall AD, Davis JB. Gunthorpe MJ, et al. Among authors: lappin sc. Neuropharmacology. 2004 Jan;46(1):133-49. doi: 10.1016/s0028-3908(03)00305-8. Neuropharmacology. 2004. PMID: 14654105
Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.
Westaway SM, Thompson M, Rami HK, Stemp G, Trouw LS, Mitchell DJ, Seal JT, Medhurst SJ, Lappin SC, Biggs J, Wright J, Arpino S, Jerman JC, Cryan JE, Holland V, Winborn KY, Coleman T, Stevens AJ, Davis JB, Gunthorpe MJ. Westaway SM, et al. Among authors: lappin sc. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5609-13. doi: 10.1016/j.bmcl.2008.08.105. Epub 2008 Aug 31. Bioorg Med Chem Lett. 2008. PMID: 18809327