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Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.
Gavai AV, Fink BE, Fairfax DJ, Martin GS, Rossiter LM, Holst CL, Kim SH, Leavitt KJ, Mastalerz H, Han WC, Norris D, Goyal B, Swaminathan S, Patel B, Mathur A, Vyas DM, Tokarski JS, Yu C, Oppenheimer S, Zhang H, Marathe P, Fargnoli J, Lee FY, Wong TW, Vite GD. Gavai AV, et al. Among authors: vite gd. J Med Chem. 2009 Nov 12;52(21):6527-30. doi: 10.1021/jm9010065. J Med Chem. 2009. PMID: 19821562
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.
Leftheris K, Kline T, Vite GD, Cho YH, Bhide RS, Patel DV, Patel MM, Schmidt RJ, Weller HN, Andahazy ML, Carboni JM, Gullo-Brown JL, Lee FY, Ricca C, Rose WC, Yan N, Barbacid M, Hunt JT, Meyers CA, Seizinger BR, Zahler R, Manne V. Leftheris K, et al. Among authors: vite gd. J Med Chem. 1996 Jan 5;39(1):224-36. doi: 10.1021/jm950642a. J Med Chem. 1996. PMID: 8568812
Synthesis and biological activity of novel epothilone aziridines.
Regueiro-Ren A, Borzilleri RM, Zheng X, Kim SH, Johnson JA, Fairchild CR, Lee FY, Long BH, Vite GD. Regueiro-Ren A, et al. Among authors: vite gd. Org Lett. 2001 Aug 23;3(17):2693-6. doi: 10.1021/ol016273w. Org Lett. 2001. PMID: 11506611
SAR and pH stability of cyano-substituted epothilones.
Regueiro-Ren A, Leavitt K, Kim SH, Höfle G, Kiffe M, Gougoutas JZ, DiMarco JD, Lee FY, Fairchild CR, Long BH, Vite GD. Regueiro-Ren A, et al. Among authors: vite gd. Org Lett. 2002 Oct 31;4(22):3815-8. doi: 10.1021/ol026589j. Org Lett. 2002. PMID: 12599466
New dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Fink BE, Vite GD, Mastalerz H, Kadow JF, Kim SH, Leavitt KJ, Du K, Crews D, Mitt T, Wong TW, Hunt JT, Vyas DM, Tokarski JS. Fink BE, et al. Among authors: vite gd. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4774-9. doi: 10.1016/j.bmcl.2005.07.027. Bioorg Med Chem Lett. 2005. PMID: 16111887
41 results