Araki T - Search Results

1

A suggested role for mitochondria in Noonan syndrome.

Lee I, Pecinova A, Pecina P, Neel BG, Araki T, Kucherlapati R, Roberts AE, Hüttemann M. Lee I, et al. Among authors: araki t. Biochim Biophys Acta. 2010 Feb;1802(2):275-83. doi: 10.1016/j.bbadis.2009.10.005. Epub 2009 Oct 14. Biochim Biophys Acta. 2010. PMID: 19835954 Free PMC article.

2

Germline gain-of-function mutations in SOS1 cause Noonan syndrome.

Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS. Roberts AE, et al. Among authors: araki t. Nat Genet. 2007 Jan;39(1):70-4. doi: 10.1038/ng1926. Epub 2006 Dec 3. Nat Genet. 2007. PMID: 17143285

3

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.

Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman C, Bronson R, Neel B, Seidman JG, Kucherlapati R. Chen PC, et al. Among authors: araki t. J Clin Invest. 2010 Dec;120(12):4353-65. doi: 10.1172/JCI43910. J Clin Invest. 2010. PMID: 21041952 Free PMC article.

4

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.

Araki T, Chan G, Newbigging S, Morikawa L, Bronson RT, Neel BG. Araki T, et al. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4736-41. doi: 10.1073/pnas.0810053106. Epub 2009 Feb 27. Proc Natl Acad Sci U S A. 2009. PMID: 19251646 Free PMC article.

5

Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.

Gauthier AS, Furstoss O, Araki T, Chan R, Neel BG, Kaplan DR, Miller FD. Gauthier AS, et al. Among authors: araki t. Neuron. 2007 Apr 19;54(2):245-62. doi: 10.1016/j.neuron.2007.03.027. Neuron. 2007. PMID: 17442246 Free PMC article.

6

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.

Araki T, Mohi MG, Ismat FA, Bronson RT, Williams IR, Kutok JL, Yang W, Pao LI, Gilliland DG, Epstein JA, Neel BG. Araki T, et al. Nat Med. 2004 Aug;10(8):849-57. doi: 10.1038/nm1084. Epub 2004 Jul 25. Nat Med. 2004. PMID: 15273746

7

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.

Wu X, Simpson J, Hong JH, Kim KH, Thavarajah NK, Backx PH, Neel BG, Araki T. Wu X, et al. Among authors: araki t. J Clin Invest. 2011 Mar;121(3):1009-25. doi: 10.1172/JCI44929. Epub 2011 Feb 21. J Clin Invest. 2011. PMID: 21339642 Free PMC article.

8

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.

De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A. De Rocca Serra-Nédélec A, et al. Among authors: araki t. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371576 Free PMC article.

9

Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.

Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T. Wu X, et al. Among authors: araki t. Mol Cell Biol. 2012 Oct;32(19):3872-90. doi: 10.1128/MCB.00751-12. Epub 2012 Jul 23. Mol Cell Biol. 2012. PMID: 22826437 Free PMC article.

10

Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth.

Tajan M, Pernin-Grandjean J, Beton N, Gennero I, Capilla F, Neel BG, Araki T, Valet P, Tauber M, Salles JP, Yart A, Edouard T. Tajan M, et al. Among authors: araki t. Hum Mol Genet. 2018 Jul 1;27(13):2276-2289. doi: 10.1093/hmg/ddy133. Hum Mol Genet. 2018. PMID: 29659837 Free PMC article.

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