Holman TR - Search Results

1

Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.

Robinson SJ, Hoobler EK, Riener M, Loveridge ST, Tenney K, Valeriote FA, Holman TR, Crews P. Robinson SJ, et al. Among authors: holman tr. J Nat Prod. 2009 Oct;72(10):1857-63. doi: 10.1021/np900465e. J Nat Prod. 2009. PMID: 19848434 Free PMC article.

2

Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors.

Carroll J, Jonsson EN, Ebel R, Hartman MS, Holman TR, Crews P. Carroll J, et al. Among authors: holman tr. J Org Chem. 2001 Oct 19;66(21):6847-51. doi: 10.1021/jo015784t. J Org Chem. 2001. PMID: 11597201

3

Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.

Amagata T, Whitman S, Johnson TA, Stessman CC, Loo CP, Lobkovsky E, Clardy J, Crews P, Holman TR. Amagata T, et al. Among authors: holman tr. J Nat Prod. 2003 Feb;66(2):230-5. doi: 10.1021/np020462l. J Nat Prod. 2003. PMID: 12608855

4

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Segraves EN, et al. Among authors: holman tr. J Med Chem. 2004 Jul 29;47(16):4060-5. doi: 10.1021/jm049872s. J Med Chem. 2004. PMID: 15267244

5

An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge.

Gautschi JT, Whitman S, Holman TR, Crews P. Gautschi JT, et al. Among authors: holman tr. J Nat Prod. 2004 Aug;67(8):1256-61. doi: 10.1021/np0340495. J Nat Prod. 2004. PMID: 15332838

6

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Cichewicz RH, et al. Among authors: holman tr. J Am Chem Soc. 2004 Nov 17;126(45):14910-20. doi: 10.1021/ja046082z. J Am Chem Soc. 2004. PMID: 15535718

7

Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis.

Cichewicz RH, Clifford LJ, Lassen PR, Cao X, Freedman TB, Nafie LA, Deschamps JD, Kenyon VA, Flanary JR, Holman TR, Crews P. Cichewicz RH, et al. Among authors: holman tr. Bioorg Med Chem. 2005 Oct 1;13(19):5600-12. doi: 10.1016/j.bmc.2005.06.020. Bioorg Med Chem. 2005. PMID: 16039133

8

Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity.

Ralifo P, Sanchez L, Gassner NC, Tenney K, Lokey RS, Holman TR, Valeriote FA, Crews P. Ralifo P, et al. Among authors: holman tr. J Nat Prod. 2007 Jan;70(1):95-9. doi: 10.1021/np060585w. J Nat Prod. 2007. PMID: 17253856 Free PMC article.

9

Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Gassner NC, Tamble CM, Bock JE, Cotton N, White KN, Tenney K, St Onge RP, Proctor MJ, Giaever G, Nislow C, Davis RW, Crews P, Holman TR, Lokey RS. Gassner NC, et al. Among authors: holman tr. J Nat Prod. 2007 Mar;70(3):383-90. doi: 10.1021/np060555t. Epub 2007 Feb 10. J Nat Prod. 2007. PMID: 17291044 Free PMC article.

10

Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR. Deschamps JD, et al. Among authors: holman tr. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. doi: 10.1016/j.bmc.2007.08.015. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17826100 Free PMC article.

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