Hoobler EK - Search Results

1

Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.

Robinson SJ, Hoobler EK, Riener M, Loveridge ST, Tenney K, Valeriote FA, Holman TR, Crews P. Robinson SJ, et al. Among authors: hoobler ek. J Nat Prod. 2009 Oct;72(10):1857-63. doi: 10.1021/np900465e. J Nat Prod. 2009. PMID: 19848434 Free PMC article.

2

Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases.

Hoobler EK, Holz C, Holman TR. Hoobler EK, et al. Bioorg Med Chem. 2013 Jul 1;21(13):3894-9. doi: 10.1016/j.bmc.2013.04.016. Epub 2013 Apr 18. Bioorg Med Chem. 2013. PMID: 23669189 Free PMC article.

3

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.

Hoobler EK, Rai G, Warrilow AG, Perry SC, Smyrniotis CJ, Jadhav A, Simeonov A, Parker JE, Kelly DE, Maloney DJ, Kelly SL, Holman TR. Hoobler EK, et al. PLoS One. 2013 Jun 24;8(6):e65928. doi: 10.1371/journal.pone.0065928. Print 2013. PLoS One. 2013. PMID: 23826084 Free PMC article.

4

Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2.

Joshi N, Hoobler EK, Perry S, Diaz G, Fox B, Holman TR. Joshi N, et al. Among authors: hoobler ek. Biochemistry. 2013 Nov 12;52(45):8026-35. doi: 10.1021/bi4010649. Epub 2013 Oct 30. Biochemistry. 2013. PMID: 24171444 Free PMC article.

5

Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.

Mascayano C, Espinosa V, Sepúlveda-Boza S, Hoobler EK, Perry S, Diaz G, Holman TR. Mascayano C, et al. Among authors: hoobler ek. Chem Biol Drug Des. 2015 Jul;86(1):114-21. doi: 10.1111/cbdd.12469. Epub 2014 Nov 28. Chem Biol Drug Des. 2015. PMID: 25359714 Free PMC article.

6

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. Rai G, et al. J Med Chem. 2010 Oct 28;53(20):7392-404. doi: 10.1021/jm1008852. J Med Chem. 2010. PMID: 20866075 Free PMC article.

7

In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases.

Mascayano C, Espinosa V, Sepúlveda-Boza S, Hoobler EK, Perry S. Mascayano C, et al. Among authors: hoobler ek. Chem Biol Drug Des. 2013 Sep;82(3):317-25. doi: 10.1111/cbdd.12157. Epub 2013 Jun 29. Chem Biol Drug Des. 2013. PMID: 23663316

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