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Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment.
Gullbo J, Fryknäs M, Rickardson L, Darcy P, Hägg M, Wickström M, Hassan S, Westman G, Brnjic S, Nygren P, Linder S, Larsson R. Gullbo J, et al. Among authors: larsson r. Biochem Pharmacol. 2011 Jul 15;82(2):139-47. doi: 10.1016/j.bcp.2011.04.003. Epub 2011 Apr 22. Biochem Pharmacol. 2011. PMID: 21531212 Free article.
AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
Eriksson A, Kalushkova A, Jarvius M, Hilhorst R, Rickardson L, Kultima HG, de Wijn R, Hovestad L, Fryknäs M, Öberg F, Larsson R, Parrow V, Höglund M. Eriksson A, et al. Among authors: larsson r. Biochem Pharmacol. 2014 Jan 15;87(2):284-91. doi: 10.1016/j.bcp.2013.10.022. Epub 2013 Nov 4. Biochem Pharmacol. 2014. PMID: 24200998 Free article. Clinical Trial.
Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model.
Fryknäs M, Rickardson L, Wickström M, Dhar S, Lövborg H, Gullbo J, Nygren P, Gustafsson MG, Isaksson A, Larsson R. Fryknäs M, et al. Among authors: larsson r. J Biomol Screen. 2006 Aug;11(5):457-68. doi: 10.1177/1087057106288048. J Biomol Screen. 2006. PMID: 16928983
525 results