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The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway.
Ray DM, Morse KM, Hilchey SP, Garcia TM, Felgar RE, Maggirwar SB, Phipps RP, Bernstein SH. Ray DM, et al. Among authors: hilchey sp. Exp Hematol. 2006 Sep;34(9):1202-11. doi: 10.1016/j.exphem.2006.04.026. Exp Hematol. 2006. PMID: 16939813 Free article.
The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore.
Brookes PS, Morse K, Ray D, Tompkins A, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R, Bernstein SH. Brookes PS, et al. Cancer Res. 2007 Feb 15;67(4):1793-802. doi: 10.1158/0008-5472.CAN-06-2678. Cancer Res. 2007. PMID: 17308122
Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab.
Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ Jr, Bankert RB, Bernstein SH. Hilchey SP, et al. Blood. 2009 Apr 16;113(16):3809-12. doi: 10.1182/blood-2008-10-185280. Epub 2009 Feb 4. Blood. 2009. PMID: 19196657 Free PMC article. Clinical Trial.
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